5-Aziridino-2,4-dinitrobenzamide
Synonym(s):5-(1-Aziridinyl)-2,4-dinitrobenzamide;5-(Aziridin-1-yl)-2,4-dinitrobenzamide
- CAS NO.：21919-05-1
- Empirical Formula: C9H8N4O5
- Molecular Weight: 252.18
- MDL number: MFCD00869490
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is 5-Aziridino-2,4-dinitrobenzamide?
Description
CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent.
The Uses of 5-Aziridino-2,4-dinitrobenzamide
5-Aziridino-2,4-dinitrobenzamide is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2.
The Uses of 5-Aziridino-2,4-dinitrobenzamide
Tretazicar is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2.
What are the applications of Application
CB 1954 is a compound for gene therapy resrearch
Biochem/physiol Actions
CB 1954 is an anticancer prodrug used in gene therapy research; activated by NAD(P)H quinone oxidoreductase?2.
Properties of 5-Aziridino-2,4-dinitrobenzamide
| Melting point: | 173 °C |
| Boiling point: | 427.2±45.0 °C(Predicted) |
| Density | 1.671±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Sl |
| form | solid |
| pka | 14.23±0.50(Predicted) |
| color | Yellow to Dark Yellow |
Safety information for 5-Aziridino-2,4-dinitrobenzamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Aziridino-2,4-dinitrobenzamide
| InChIKey | WOCXQMCIOTUMJV-UHFFFAOYSA-N |
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