4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
- CAS NO.：63597-44-4
- Empirical Formula: C36H56O8
- Molecular Weight: 616.83
- MDL number: MFCD00153860
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:21:42
What is 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE?
The Uses of 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.
What are the applications of Application
4α-Phorbol 12-myristate 13-acetate is a phorbol ester analog, binds to TRPV4, increases PGHS-2 mRNA in murine keratinocytes
Biochem/physiol Actions
Negative control for phorbol ester activation of protein kinase C.
Properties of 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
| storage temp. | -20°C |
| solubility | H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media. |
| form | solid |
| color | white |
| Sensitive | Light Sensitive |
Safety information for 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
Computed Descriptors for 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
New Products
Dexamethasone Sodium Phosphate p-Anisaldehyde m-Tolualdehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid Raloxifene EP Impurity D N-Nitroso Nortriptyline Nitroso Irbesartan 2-(p-Tolyl)acetaldehyde Sulfonic acid Impurity 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one 5-Chloro-2-Methoxy-4-Picoline 2-Amino-6-nitrobenzoic Acid (6-Nitroanthranilic acid) Cis-3,5 Diacetoxy-1-cyclopentene 3-Bromo-2-Methoxy-4-Methylpyridine 2-Amino-5-Chloro-3-Nitro-6-picoline 3-Methoxy-5-methylpyrazin-2-amine Pentachlorobenzonitrile Budesonide Nicotinic acid RAPAMYCIN Alpha CyclodextrinRelated products of tetrahydrofuran
You may like
-
4α-Phorbol 12-myristate 13-acetate CAS 63597-44-4View Details
63597-44-4 -
12029-98-0 >98%View Details
12029-98-0 -
1177-87-3 Dexamethasone Acetate >98%View Details
1177-87-3 -
Hydrocortisone 50-23-7 >98%View Details
50-23-7 -
106-43-4 Parachlorotoluene >99%View Details
106-43-4 -
Pyrrolidin >98%View Details
123-75-1 -
cis-p-Menth-2,8-diene-1-ol 7212-40-0 >98%View Details
7212-40-0 -
Para Chloro toluene (PCT) 106-43-4 >99%View Details
106-43-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.