4,6-DIOXOHEPTANOIC ACID

Synonym(s):Succinylacetone;Succinylacetone-3,4,5,6,7-¹³C₅

CAS NO.：51568-18-4
Empirical Formula: C7H10O4
Molecular Weight: 158.15
MDL number: MFCD00002797
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-10 18:04:36

What is 4,6-DIOXOHEPTANOIC ACID?

Chemical properties

White Solid

The Uses of 4,6-DIOXOHEPTANOIC ACID

4,6-Dioxoheptanoic acid has been used:

as component of dendritic cell conditioning medium and in the inhibition of ALA dehydratase (ALAD) in dendritic cells(50)
as an inhibitor of heme biosynthesis in human mononuclear cells(51) and HeLa cells(52)
as a standard for the quantification of succinylacetone from Plasmodium falciparum cultures(53)

The Uses of 4,6-DIOXOHEPTANOIC ACID

Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It was developed a stable-isotope quid urine using a 13C4-SA as internal standard.

What are the applications of Application

Succinylacetone is a catabolic byproduct of tyrosine breakdown and an inhbitor of heme biosynthesis.

Definition

ChEBI: A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.

Biochem/physiol Actions

4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns.

Properties of 4,6-DIOXOHEPTANOIC ACID

Melting point:	66-67 °C(lit.)
Boiling point:	318.7±17.0 °C(Predicted)
Density	1.189±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	powder
pka	4.54±0.17(Predicted)
color	White to Off-White
CAS DataBase Reference	51568-18-4

Safety information for 4,6-DIOXOHEPTANOIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.