4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE

Synonym(s):4,4′-Diamino-3,3′-dimethyldiphenylmethane;4,4′-Methylene-di(o-toluidine)

CAS NO.：838-88-0
Empirical Formula: C15H18N2
Molecular Weight: 226.32
MDL number: MFCD00126963
EINECS: 212-658-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-02-10 11:39:28

4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE Structural

What is 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE?

Chemical properties

White powder. Soluble in ethanol and hot water.

The Uses of 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE

4,4'-Diamino-3,3'-dimethyldiphenylmethane can be used for preparation polyimide and epoxy resin material.

The Uses of 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE

4,4′-Methylene-bis(2-methylaniline) has been used as a reference standard for the determination of 4,4′-methylene-bis(2-methylaniline) in plastic multilayer food packaging materials by liquid chromatography (LC)-Orbitrap-full scan-high resolution mass spectrometry (HRMS).
It may be used as a reference standard for the analysis of 4,4′-methylene-bis(2-methylaniline) in dyes, cosmetics, finger paints and inks for pens and tattoos by LC-MS.

Definition

ChEBI: 4,4'-Methylene bis(2-methylaniline) is a diarylmethane.

General Description

4,4′-Methylene-bis(2-methylaniline) belongs to the primary aromatic amines (PAAs) family of compounds which are toxic in nature and are probable human carcinogens.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion. An eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Properties of 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE

Melting point:	155-157 °C
Boiling point:	357.94°C (rough estimate)
Density	0.9543 (rough estimate)
vapor pressure	1.8hPa at 205.5℃
refractive index	1.5000 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Water Solubility	Insoluble in water
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	5.18±0.25(Predicted)
form	neat
color	White to Light yellow to Light orange
BRN	398069
CAS DataBase Reference	838-88-0(CAS DataBase Reference)
IARC	2B (Vol. 4, Sup 7) 1987
EPA Substance Registry System	4,4'-Methylenebis(2-methylaniline) (838-88-0)

Safety information for 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin H350:Carcinogenicity H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention.