4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride
Synonym(s):Fluolead
- CAS NO.:947725-04-4
- Empirical Formula: C12H17F3S
- Molecular Weight: 250.32
- MDL number: MFCD11858620
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:31:54
What is 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride?
Chemical properties
White powder
The Uses of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride
4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride is a deoxofluorination reagent used in an improved method of synthesis of arylsulfur trifluorides.
The Uses of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride
Air and thermally stable alternative to DAST. Efficient deoxofluorinating agent for a wide variety of substrates.
The Uses of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride
Features:
- Tolerance of many functional groups
- Highly selective functionalization
- Highly efficient and broad reaction scope
- Mild reaction conditions
Generally superior reactivity and selectivity to SF4 and easier and safer to handle.
Shown to promote nucleophilic deoxofluorination reactions and exhibits excellent thermal stability, up to 150 °C, therefore rendering it safely applicable in a variety of processes, including industrial scale production.
Novel fluorinating reagent applicable to a variety of chemical processes (Scheme 1).
Refer to the Datasheet for more information on Fluolead?: A Novel New Versatile Fluorinating Agent
General Description
4-tert-Butyl-2,6-dimethylphenylsulfur trifluoride is a thermally stable, easy-to-handle, versatile deoxofluorinating agent that also shows high stability on contact with water. It is a superior alternative to diethylaminosulfur trifluoride (DAST).
Properties of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride
| Melting point: | 62-68 °C |
| Boiling point: | 92-93℃ (0.5 Torr) |
| Density | 1.07±0.1 g/cm3(Predicted) |
| storage temp. | 0-10°C |
| form | crystal |
| color | white to off-white |
Safety information for 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride
| Signal word | Danger |
| Pictogram(s) |
![]() Corrosion Corrosives GHS05 ![]() Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H290:Corrosive to Metals H301:Acute toxicity,oral H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P390:Absorb spillage to prevent material damage. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride
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