4-Phenylpyridine

CAS NO.：939-23-1
Empirical Formula: C11H9N
Molecular Weight: 155.2
MDL number: MFCD00006420
EINECS: 213-357-4
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 4-Phenylpyridine?

Chemical properties

LIGHT YELLOW TO BEIGE CRYSTALLINE POWDER

The Uses of 4-Phenylpyridine

4-Phenylpyridine is a useful synthetic intermediate. 4-Phenylpyridine has been shown to induce inhibition of mitochondrial respiration in mice.

Definition

ChEBI: 4-Phenylpyridine is a phenylpyridine.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 1702, 1956 DOI: 10.1021/ja01589a060
Synthetic Communications, 21, p. 619, 1991 DOI: 10.1080/00397919108020828
Tetrahedron Letters, 36, p. 5247, 1995 DOI: 10.1016/0040-4039(95)00983-J

Enzyme inhibitor

This substituted pyridine (FW = 155.20 g/mol; CAS 939-23-1; M.P. = 69- 73°C; B.P. = 274-275°C), which occurs naturally and is likewise a manmade pollutant, inhibits human placental aromatase, Ki = 0.36 μM, monoamine oxidase, and NADH dehydrogenase. 4-Phenylpyridine is also an effective inhibitor of mitochondrial complex I. Note that it both occurs naturally and is an environmental pollutant.

Properties of 4-Phenylpyridine

Melting point:	69-73 °C (lit.)
Boiling point:	274-275 °C (lit.)
Density	1.1088 (rough estimate)
refractive index	1.6210 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Methanol
form	Crystalline Powder
pka	5.45±0.10(Predicted)
color	Light yellow to beige
Water Solubility	SOLUBLE
BRN	110490
CAS DataBase Reference	939-23-1(CAS DataBase Reference)
NIST Chemistry Reference	4-phenyl-pyridine(939-23-1)
EPA Substance Registry System	4-Phenylpyridine (939-23-1)

Safety information for 4-Phenylpyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.