4-Phenylpyridine
- CAS NO.：939-23-1
- Empirical Formula: C11H9N
- Molecular Weight: 155.2
- MDL number: MFCD00006420
- EINECS: 213-357-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:19:25
What is 4-Phenylpyridine?
Chemical properties
LIGHT YELLOW TO BEIGE CRYSTALLINE POWDER
The Uses of 4-Phenylpyridine
4-Phenylpyridine is a useful synthetic intermediate. 4-Phenylpyridine has been shown to induce inhibition of mitochondrial respiration in mice.
Definition
ChEBI: 4-Phenylpyridine is a phenylpyridine.
Synthesis Reference(s)
Journal of the American Chemical Society, 78, p. 1702, 1956 DOI: 10.1021/ja01589a060
Synthetic Communications, 21, p. 619, 1991 DOI: 10.1080/00397919108020828
Tetrahedron Letters, 36, p. 5247, 1995 DOI: 10.1016/0040-4039(95)00983-J
Enzyme inhibitor
This substituted pyridine (FW = 155.20 g/mol; CAS 939-23-1; M.P. = 69- 73°C; B.P. = 274-275°C), which occurs naturally and is likewise a manmade pollutant, inhibits human placental aromatase, Ki = 0.36 μM, monoamine oxidase, and NADH dehydrogenase. 4-Phenylpyridine is also an effective inhibitor of mitochondrial complex I. Note that it both occurs naturally and is an environmental pollutant.
Properties of 4-Phenylpyridine
| Melting point: | 69-73 °C (lit.) |
| Boiling point: | 274-275 °C (lit.) |
| Density | 1.1088 (rough estimate) |
| refractive index | 1.6210 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform, Methanol |
| form | Crystalline Powder |
| pka | 5.45±0.10(Predicted) |
| color | Light yellow to beige |
| Water Solubility | SOLUBLE |
| BRN | 110490 |
| CAS DataBase Reference | 939-23-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-phenyl-pyridine(939-23-1) |
| EPA Substance Registry System | 4-Phenylpyridine (939-23-1) |
Safety information for 4-Phenylpyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Phenylpyridine
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