4-PHENYL-3-BUTYN-2-ONE
- CAS NO.：1817-57-8
- Empirical Formula: C10H8O
- Molecular Weight: 144.17
- MDL number: MFCD00008776
- EINECS: 217-327-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:35:10
What is 4-PHENYL-3-BUTYN-2-ONE?
The Uses of 4-PHENYL-3-BUTYN-2-ONE
It is used as pharmaceutical intermediate.
Definition
ChEBI: 4-phenylbut-3-yn-2-one is a ynone.
Synthesis Reference(s)
Chemistry Letters, 9, p. 1327, 1980
The Journal of Organic Chemistry, 47, p. 2549, 1982 DOI: 10.1021/jo00134a010
Tetrahedron Letters, 29, p. 2321, 1988 DOI: 10.1016/S0040-4039(00)86048-7
General Description
4-Phenyl-3-butyn-2-one is an α,β-ketoalkyne. Reaction of 4-phenyl-3-butyn-2-one with bromine chloride and iodine monochloride in CH2Cl2, CH2Cl2/pyridine and MeOH are studied. Reduction of 4-phenyl-3-butyn-2-one in THF solution has been reported.
Properties of 4-PHENYL-3-BUTYN-2-ONE
| Melting point: | 4°C |
| Boiling point: | 75-76 °C/0.8 mmHg (lit.) |
| Density | 0.99 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 203 °F |
| storage temp. | 2-8°C |
| form | clear liquid |
| Specific Gravity | 1.02 |
| color | Colorless to Yellow to Green |
| Water Solubility | Insoluble in water. |
| CAS DataBase Reference | 1817-57-8(CAS DataBase Reference) |
Safety information for 4-PHENYL-3-BUTYN-2-ONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see … on this label). P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 4-PHENYL-3-BUTYN-2-ONE
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