4-NITROQUINOLINE N-OXIDE

Chemical properties

yellow-brown crystals or powder

The Uses of 4-NITROQUINOLINE N-OXIDE

4-Nitroquinoline N-Oxide is used in method for constructing animal model of oral mucosal malignancy related to Kras mutation.

The Uses of 4-NITROQUINOLINE N-OXIDE

4-Nitroquinoline N-oxide has been used as a model compound to study its carcinogenic effects.

What are the applications of Application

4-Nitroquinoline N-oxide is a model compound uesd to study carcinogenic effects, as it itself is a skin and lung tumor initiator.

Definition

ChEBI: A quinoline N-oxide carrying a nitro substituent at position 4.

General Description

Yellowish-brown plates or needles or yellow solid.

Air & Water Reactions

4-NITROQUINOLINE N-OXIDE is hygroscopic and light sensitive. Insoluble in water.

Reactivity Profile

4-NITROQUINOLINE N-OXIDE reacts with strong oxidizing agents.

Health Hazard

ACUTE/CHRONIC HAZARDS: 4-NITROQUINOLINE N-OXIDE may cause irritation. When heated to decomposition it may emit toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.

Fire Hazard

Flash point data for 4-NITROQUINOLINE N-OXIDE are not available; however, 4-NITROQUINOLINE N-OXIDE is probably combustible.

Biochem/physiol Actions

Skin and lung tumor initiator under experimental conditions.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplas tigenic, and tumorigenic data. Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The N-oxide recrystallises from aqueous acetone as yellow needles or platelets. [Ochiai J Org Chem 18 534 1953, Seki et al. J Phys Chem 91 126 1987, Beilstein 20 III/IV 3396.]