4-NITROPHENYL ACETATE
Synonym(s):Acetic acid 4-nitrophenyl ester
- CAS NO.：830-03-5
- Empirical Formula: C8H7NO4
- Molecular Weight: 181.15
- MDL number: MFCD00007326
- EINECS: 212-593-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:22:19
What is 4-NITROPHENYL ACETATE?
Chemical properties
off-white or beige powder
The Uses of 4-NITROPHENYL ACETATE
4-Nitrophenyl Acetate have been used as a substrate to study for the enzymatic activity of Carbonic Anhydrase III isolated from bovine skeletal muscle.
The Uses of 4-NITROPHENYL ACETATE
4-Nitrophenyl acetate is used with iodoacetic acid for reductive cleavage of methionine-containing peptides. It is also used as a substrate that has been used in assays for esterase and lipase activity. Inorganic complexes have been evaluated for their methanolysis or hydrolysis activity using p-nitrophenyl acetate.
What are the applications of Application
4-Nitrophenyl acetate is a chromogenic esterase substrate
Definition
ChEBI: An acetate ester resulting from the formal condensation of the hydroxy group of 4-nitrophenol with the carboxy group of acetic acid.
Synthesis Reference(s)
Synthesis, p. 991, 1981 DOI: 10.1055/s-1981-29674
Safety Profile
Poison by intravenous route. Whenheated to decomposition it emits toxic fumes of NOx.
Purification Methods
Recrystallise the ester from absolute EtOH [Moss et al. J Am Chem Soc 108 5520 1986]. [Beilstein 6 IV 1298.]
Properties of 4-NITROPHENYL ACETATE
| Melting point: | 75-77 °C (lit.) |
| Boiling point: | 314.24°C (rough estimate) |
| Density | 1.4283 (rough estimate) |
| vapor pressure | 1.28Pa at 20℃ |
| refractive index | 1.5468 (estimate) |
| storage temp. | -20°C |
| solubility | 0.53g/l |
| form | Powder |
| color | Green |
| Water Solubility | Insoluble in water. |
| BRN | 515874 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 830-03-5(CAS DataBase Reference) |
| EPA Substance Registry System | Acetic acid, 4-nitrophenyl ester (830-03-5) |
Safety information for 4-NITROPHENYL ACETATE
| Signal word | Danger |
| Pictogram(s) |
 Flame Over Circle Oxidizers GHS03  Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H272:Oxidising liquids;Oxidising solids H317:Sensitisation, Skin H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P220:Keep/Store away from clothing/…/combustible materials. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-NITROPHENYL ACETATE
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