4-(Methylsulfonyl)phenol
Synonym(s):4-Hydroxyphenyl methyl sulfone
- CAS NO.：14763-60-1
- Empirical Formula: C7H8O3S
- Molecular Weight: 172.2
- MDL number: MFCD00047806
- EINECS: 632-596-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 17:18:21
What is 4-(Methylsulfonyl)phenol?
Chemical properties
Tan to pink-brown powder
The Uses of 4-(Methylsulfonyl)phenol
4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.
Reactions
The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).
Properties of 4-(Methylsulfonyl)phenol
| Melting point: | 90-95 °C |
| Boiling point: | 272.52°C (rough estimate) |
| Density | 1.3692 (rough estimate) |
| RTECS | SM1530000 |
| refractive index | 1.5151 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Methanol |
| form | Powder |
| pka | pK1:7.83 (25°C) |
| color | Tan to pink-brown |
| Water Solubility | slight |
| BRN | 1866322 |
| CAS DataBase Reference | 14763-60-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-(Methylsulfonyl)phenol(14763-60-1) |
Safety information for 4-(Methylsulfonyl)phenol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H303:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(Methylsulfonyl)phenol
New Products
9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde 4 pentyn 1 ol N-Vinylformamide Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 4-Nitrobenzotrifluoride 2-Pentyn-1-oL N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
![4-((4-[(3-CHLORO-2,2-DIMETHYLPROPANOYL)OXY]-3,5-DIMETHYLPHENYL)SULFONYL)-2,6-DIMETHYLPHENYL 3-CHLORO-2,2-DIMETHYLPROPANOATE](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB0419734.gif)
![Bis[4-(4-aminophenoxy)phenyl]sulfone](https://img.chemicalbook.in/CAS/GIF/13080-89-2.gif)
You may like
-
4-Hydroxyphenyl Methyl Sulfone CAS 14763-60-1View Details
14763-60-1 -
1191-95-3 Cyclobutanone 98+View Details
1191-95-3 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1 -
1191-95-3 Cyclobutanone 98+View Details
1191-95-3 -
213382-45-7 98+View Details
213382-45-7 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.