4-(Methylsulfonyl)phenol
Synonym(s):4-Hydroxyphenyl methyl sulfone
- CAS NO.：14763-60-1
- Empirical Formula: C7H8O3S
- Molecular Weight: 172.2
- MDL number: MFCD00047806
- EINECS: 632-596-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:59:15
What is 4-(Methylsulfonyl)phenol?
Chemical properties
Tan to pink-brown powder
The Uses of 4-(Methylsulfonyl)phenol
4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.
Reactions
The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).
Properties of 4-(Methylsulfonyl)phenol
| Melting point: | 90-95 °C |
| Boiling point: | 272.52°C (rough estimate) |
| Density | 1.3692 (rough estimate) |
| RTECS | SM1530000 |
| refractive index | 1.5151 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Methanol |
| form | Powder |
| pka | pK1:7.83 (25°C) |
| color | Tan to pink-brown |
| Water Solubility | slight |
| BRN | 1866322 |
| CAS DataBase Reference | 14763-60-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-(Methylsulfonyl)phenol(14763-60-1) |
Safety information for 4-(Methylsulfonyl)phenol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H303:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(Methylsulfonyl)phenol
New Products
3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Pentadecanoic acid Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 5-Bromo-2-Fluoropyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 4-Bromo-3-(ethoxymethyl)benzoic acid 2,4-Dichloro-5-methoxyaniline 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine N2-Isobutyryl-2'-O-methylguanosine 2-chloro-5-methylpyridin-4-amine 4-Bromobenzaldehyde 2-Chloro-6-nitro benzothiazole 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-one 5-Phenyl-[1,3,4]-thiadiazol-2-amineRelated products of tetrahydrofuran
![4-((4-[(3-CHLORO-2,2-DIMETHYLPROPANOYL)OXY]-3,5-DIMETHYLPHENYL)SULFONYL)-2,6-DIMETHYLPHENYL 3-CHLORO-2,2-DIMETHYLPROPANOATE](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB0419734.gif)
![Bis[4-(4-aminophenoxy)phenyl]sulfone](https://img.chemicalbook.in/CAS/GIF/13080-89-2.gif)
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