4-Methyl-2-(1-piperidinyl)-quinoline

Synonym(s):4-Methyl-2-(1-piperidinyl)-quinoline

CAS NO.：5465-86-1
Empirical Formula: C15H18N2
Molecular Weight: 226.32
MDL number: MFCD00817920
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:04:34

4-Methyl-2-(1-piperidinyl)-quinoline Structural

What is 4-Methyl-2-(1-piperidinyl)-quinoline?

Description

ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC₅₀s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

The Uses of 4-Methyl-2-(1-piperidinyl)-quinoline

4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation, muscle response due to interaction with the environment.

The Uses of 4-Methyl-2-(1-piperidinyl)-quinoline

4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation and muscle response due to interaction with the environment.

Biochem/physiol Actions

ML204 is a potent and selective TRPC4 channel inhibitor.

Storage

Store at +4°C

Properties of 4-Methyl-2-(1-piperidinyl)-quinoline

Melting point:	72-73 °C
Boiling point:	177-180 °C(Press: 4.5 Torr)
Density	1.102±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL at warmed (clear solution)
form	powder
pka	7.34±0.61(Predicted)
color	white to beige

Safety information for 4-Methyl-2-(1-piperidinyl)-quinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.