4-methoxy-3-methylaniline
- CAS NO.：136-90-3
- Empirical Formula: C8H11NO
- Molecular Weight: 137.18
- MDL number: MFCD07779234
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:11:58
What is 4-methoxy-3-methylaniline?
The Uses of 4-methoxy-3-methylaniline
4-Methoxy-3-methylaniline is used in preparation of triamine pyrimidine derivatives as antitumor agents.
Synthesis
The synthesis of 4-methoxy-3-methylaniline is as follows:
4-Methoxy-3-methyl-phenylamine10% Palladium on carbon (10% Pd/C) (1.5 g) was added to a solution of 1 -methoxy-2- methyl-4-nitrobenzene (9.5 g, 57 mmol) in methanol (100 ml_). The mixture was stirred under a hydrogen atmosphere (1 atm.) at room temperature for 16 h. The mixture was filtered through a pad of CELITE and the filtrate was evaporated in vacuo to yield 4- methoxy-3-methylphenylamine (8.0 g, 57 mmol, 100%).
Properties of 4-methoxy-3-methylaniline
| Melting point: | 57-60℃ |
| Boiling point: | 252.03°C (rough estimate) |
| Density | 1.0630 (rough estimate) |
| refractive index | 1.5360 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 5.32±0.10(Predicted) |
| form | Solid |
| color | Dark Red to Black |
Safety information for 4-methoxy-3-methylaniline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-methoxy-3-methylaniline
4-methoxy-3-methylaniline manufacturer
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