4-Hydroxyphenylpyruvic acid
Synonym(s):3-(4-Hydroxyphenyl)-2-oxopropanoic acid
- CAS NO.：156-39-8
- Empirical Formula: C9H8O4
- Molecular Weight: 180.16
- MDL number: MFCD00002591
- EINECS: 205-852-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-02-02 18:10:39
What is 4-Hydroxyphenylpyruvic acid?
Chemical properties
grey to orange-brown powder
The Uses of 4-Hydroxyphenylpyruvic acid
4-Hydroxyphenylpyruvic Acid is general organic reagent used in the synthesis of latifolicinin A analogs as inhibitors of breast cancer. Also used in the preparation of amperometric biosensors for β-triketone herbicides based on hydroxyphenylpyruvate.
What are the applications of Application
4-Hydroxyphenylpyruvic acid is an enzyme inhibitor
Definition
ChEBI: An oxo carboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.
General Description
4-hydroxyphenylpyruvic acid can be determined in pork meat and Iberian ham samples by a sensitive method of multiple reaction monitoring (MRM) by mass spectrometry.
Purification Methods
p-Hydroxyphenylpyruvic acid [156-39-8] M 180.2, m 220o(dec), pKEst ~2.3. Crystallise it three times from 0.1M HCl/EtOH (4:1, v/v) immediately before use [Rose & Powell Biochem J 87 541 1963], or from Et2O. The 3,4-dinitrophenylhydrazone has m 178o. [Beilstein 10 IV 3630.]
Properties of 4-Hydroxyphenylpyruvic acid
| Melting point: | 219-220 °C (dec.) (lit.) |
| Boiling point: | 272.96°C (rough estimate) |
| Density | 1.2933 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | ethanol: soluble50mg/mL |
| form | crystalline |
| pka | 2.50±0.54(Predicted) |
| color | off-white to tan |
| Water Solubility | slightly soluble |
| BRN | 2691632 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 156-39-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenepropanoic acid, 4-hydroxy-«alpha»-oxo-(156-39-8) |
Safety information for 4-Hydroxyphenylpyruvic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 4-Hydroxyphenylpyruvic acid
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