4'-Hydroxyphenyl Carvedilol
Synonym(s):4′-Hydroxy carvedilol;4′-Hydroxyphenyl carvedilol;4′-OH carvedilol;4′OH-CVD;4-(2-(3-(9H-carbazol-4-yloxy)-2-hydroxypropylamino)ethoxy)-3-methoxyphenol
- CAS NO.：142227-49-4
- Empirical Formula: C24H26N2O5
- Molecular Weight: 422.47
- MDL number: MFCD04039561
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-21 22:16:43
What is 4'-Hydroxyphenyl Carvedilol?
Description
4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity. It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6. 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.
Chemical properties
Off-White Solid
The Uses of 4'-Hydroxyphenyl Carvedilol
4'-Hydroxyphenyl Carvedilol is an optically active metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.
The Uses of 4'-Hydroxyphenyl Carvedilol
A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.
The Uses of 4'-Hydroxyphenyl Carvedilol
An optically active metabolite of Carvedilol (C184625), a nonselective ?-adrenergic blocker with α1-blocking activity.
What are the applications of Application
4′-Hydroxyphenyl Carvedilol is a multiple-action, neurohormonal antagonist
Definition
ChEBI: 4'-Hydroxyphenyl Carvedilol is a member of carbazoles.
Properties of 4'-Hydroxyphenyl Carvedilol
| Melting point: | 163-165°C |
| Boiling point: | 702.0±60.0 °C(Predicted) |
| Density | 1.305±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.94±0.20(Predicted) |
| color | White to Light Brown |
Safety information for 4'-Hydroxyphenyl Carvedilol
Computed Descriptors for 4'-Hydroxyphenyl Carvedilol
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