4-HYDROXYPHENOXYACETIC ACID
- CAS NO.：1878-84-8
- Empirical Formula: C8H8O4
- Molecular Weight: 168.15
- MDL number: MFCD00014362
- EINECS: 217-525-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:45:42
What is 4-HYDROXYPHENOXYACETIC ACID?
Chemical properties
off-white to beige fine crystalline powder
The Uses of 4-HYDROXYPHENOXYACETIC ACID
2-(4-Hydroxyphenoxy)acetic Acid is used in the design, synthesis and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hyroxyphenylpyruvate dioxygenase. Acts as a reagent in the preparation, anti-HIV and kinesin Eg5 inhibitory activities, QSAR, and modeling studies of triazolothiadiazole and triazolothiadiazine derivatives. Synthesis of thiadiazolotriazin-4-ones and study of their mosquito-larvicidal and antibacterial properties.
Definition
ChEBI: 4-Hydroxypheoxyacetate is a monocarboxylic acid.
General Description
(4-Hydroxyphenoxy)acetic acid along with formaldehyde ammonium salt forms a polyaromatic anionic compound RG-13577. RG-13577 mimics the synthetic heparin and specifically binds to the vascular smooth muscle cells (SMCs) and inhibits their proliferative growth. In the molecules of (4-hydroxyphenoxy)acetic acid, the carboxyl groups are held together by R22(8) hydrogen bonds.
Properties of 4-HYDROXYPHENOXYACETIC ACID
| Melting point: | 154-157 °C (lit.) |
| Boiling point: | 372.6±17.0 °C(Predicted) |
| Density | 1.367±0.06 g/cm3(Predicted) |
| solubility | soluble in Methanol |
| form | Fine Crystalline Powder |
| pka | 3.27±0.10(Predicted) |
| color | Off-white to beige |
| BRN | 1952779 |
| CAS DataBase Reference | 1878-84-8(CAS DataBase Reference) |
| EPA Substance Registry System | Acetic acid, (4-hydroxyphenoxy)- (1878-84-8) |
Safety information for 4-HYDROXYPHENOXYACETIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-HYDROXYPHENOXYACETIC ACID
New Products
2-Bromo-4-hydroxypyridine 2-Benzyl-1,1,3,3-tetramethylisoindoline AMINO-O-TOLYL-ACETIC ACID AMINO(2-BROMOPHENYL)ACETIC ACID 6-BROMOTETRAZOLO[1,5-A]PYRIDINE 3-Oxocyclobutanecarboxylic acid 1,3-Diazaspiro[4.5]decane-2,4-dione, 8,8-difluoro- AMINO-(3-FLUORO-PHENYL)-ACETIC ACID Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Obidoxime hydrochloride API Piperazine, 1-(3-methoxyphenyl)-, hydrochloride (1:1) Decanoic acid, 2-[4-(phenylmethoxy)phenyl]ethyl ester 2,4-Dihydroxybenzaldehyde 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide 1-(2, 4-dichlorophenyl)-N-(2, 4-difluorophenyl)-N isopropyl-5-oxo-1H-1, 2, 4-trizole-4(5H)-carboxamide 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
![3-CHLORO-2-(4-METHOXYPHENOXY)-4-[2-(4-NITROPHENYL)HYDRAZONO]BUT-2-ENOIC ACID](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB2395861.gif)
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