4-Hydroxyphenoxyacetic acid

CAS NO.：1878-84-8
Empirical Formula: C8H8O4
Molecular Weight: 168.15
MDL number: MFCD00014362
EINECS: 217-525-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:50:05

What is 4-Hydroxyphenoxyacetic acid?

Chemical properties

off-white to beige fine crystalline powder

The Uses of 4-Hydroxyphenoxyacetic acid

2-(4-Hydroxyphenoxy)acetic Acid is used in the design, synthesis and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hyroxyphenylpyruvate dioxygenase. Acts as a reagent in the preparation, anti-HIV and kinesin Eg5 inhibitory activities, QSAR, and modeling studies of triazolothiadiazole and triazolothiadiazine derivatives. Synthesis of thiadiazolotriazin-4-ones and study of their mosquito-larvicidal and antibacterial properties.

Definition

ChEBI: 4-Hydroxypheoxyacetate is a monocarboxylic acid.

General Description

(4-Hydroxyphenoxy)acetic acid along with formaldehyde ammonium salt forms a polyaromatic anionic compound RG-13577. RG-13577 mimics the synthetic heparin and specifically binds to the vascular smooth muscle cells (SMCs) and inhibits their proliferative growth. In the molecules of (4-hydroxyphenoxy)acetic acid, the carboxyl groups are held together by R₂²(8) hydrogen bonds.

Properties of 4-Hydroxyphenoxyacetic acid

Melting point:	154-157 °C (lit.)
Boiling point:	372.6±17.0 °C(Predicted)
Density	1.367±0.06 g/cm3(Predicted)
solubility	soluble in Methanol
form	Fine Crystalline Powder
pka	3.27±0.10(Predicted)
color	Off-white to beige
BRN	1952779
CAS DataBase Reference	1878-84-8(CAS DataBase Reference)
EPA Substance Registry System	Acetic acid, (4-hydroxyphenoxy)- (1878-84-8)

Safety information for 4-Hydroxyphenoxyacetic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.