4-(Hydroxyamino)-4-oxobutanoic acid
- CAS NO.：4743-99-1
- Empirical Formula: C4H7NO4
- Molecular Weight: 133.1
- EINECS: 225-255-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-13 17:19:14
What is 4-(Hydroxyamino)-4-oxobutanoic acid?
Preparation
To a refluxing solution of 5.0 gm (0.05 mole) of succinic anhydride in 100 ml of benzene is added a solution of 6.3 gm (0.05 mole) of O-ben- zylhydroxylamine in 20 ml of benzene. As soon as the addition has been completed, the reaction mixture is cooled, and the precipitated product is separated. Upon recrystallization from a benzene-methyl ethyl ketone mixture, 7.6 gm (68.2%) of N-benzyloxysuccinamic acid, m.p. 95-96°C isolated.
A suspension of 4.3 gm (0.0193 mole) of this intermediate and a stron- tium carbonate catalyst containing 5% palladium in methyl ethyl ketone is hydrogenated. Upon working up the reaction mixture, 1.45 gm (56.7%) of succinomonohydroxamic acid, m.p. 95-96°C is isolated.
Properties of 4-(Hydroxyamino)-4-oxobutanoic acid
| Melting point: | 82-86 °C(Solv: acetonitrile (75-05-8)) |
| Density | 1.436±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 5.28±0.10(Predicted) |
Safety information for 4-(Hydroxyamino)-4-oxobutanoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(Hydroxyamino)-4-oxobutanoic acid
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