4-Chloroquinoline
- CAS NO.：611-35-8
- Empirical Formula: C9H6ClN
- Molecular Weight: 163.6
- MDL number: MFCD00006773
- EINECS: 210-267-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:14:17
What is 4-Chloroquinoline?
Chemical properties
Pale yellow low melting solid
The Uses of 4-Chloroquinoline
4-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Purification Methods
Possible impurities include the 2-isomer. It is best purified by converting to the picrate (m 212-213o dec) in EtOH and recrystallising it from EtOH (where the picrate of the 2-chloroquinoline remains in solution) or EtOAc . The picrate is decomposed with 5% aqueous NaOH, extracted in CHCl3, washed with H2O, dried (MgSO4), evaporated and distilled in a vacuum. It can be steam distilled from slightly alkaline aqueous solutions, the aqueous distillate is extracted with Et2O, evaporated and distilled. The distillate solidifies on cooling. [Bobránski Chem Ber 71 578 1938, Beilstein 20/7 V 314.]
Properties of 4-Chloroquinoline
| Melting point: | 28-31 °C (lit.) |
| Boiling point: | 260-261 °C (lit.) |
| Density | 1.25 g/mL at 20 °C (lit.) |
| refractive index | 1.6110 (estimate) |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to lump |
| pka | 3.57±0.13(Predicted) |
| color | White to Almost white |
| Water Solubility | Partly soluble in water. |
| λmax | 316nm(EtOH aq.)(lit.) |
| BRN | 114721 |
| CAS DataBase Reference | 611-35-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Chloroquinoline(611-35-8) |
Safety information for 4-Chloroquinoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Chloroquinoline
| InChIKey | KNDOFJFSHZCKGT-UHFFFAOYSA-N |
4-Chloroquinoline manufacturer
NSR Amino Organics
1Y
Phone:+91-9866989891
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product: 611-35-8 4-Chloro Quinoline 98%
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