4-Chlorobenzhydrylchloride

CAS NO.：134-83-8
Empirical Formula: C13H10Cl2
Molecular Weight: 237.12
MDL number: MFCD00000856
EINECS: 205-158-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 4-Chlorobenzhydrylchloride?

Chemical properties

clear light yellow liquid

The Uses of 4-Chlorobenzhydrylchloride

1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.

Preparation

Preparation of 4-Chlorobenzhydryl Chloride (4-CBC): The 4-chlorobenzhydrol (4-CB) in 15 mL of toluene, obtained from the previous step, was mixed with 10 mL of conc. HCl at 60oC maintained at the same temperature for 2.5 h. The reaction mixture was cooled to 20oC to separate into organic and aqueous layers. The toluene layer was washed with 10 % aq. sodium carbonate to pH 7, dried over anhydrous sodium sulphate and taken to next step without isolation.

Properties of 4-Chlorobenzhydrylchloride

Boiling point:	159-160 °C2 mm Hg(lit.)
Density	1.239 g/mL at 25 °C(lit.)
refractive index	n20/D 1.603(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form	clear liquid
color	Colorless to Light yellow to Light orange
Water Solubility	IMMISCIBLE
Sensitive	Moisture Sensitive
BRN	2050236
CAS DataBase Reference	134-83-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-chloro-4-(chlorophenylmethyl)-(134-83-8)
EPA Substance Registry System	Benzene, 1-chloro-4-(chlorophenylmethyl)- (134-83-8)

Safety information for 4-Chlorobenzhydrylchloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H314:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H400:Hazardous to the aquatic environment, acute hazard H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P501:Dispose of contents/container to..…