4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID

CAS NO.：52240-25-2
Empirical Formula: C11H11ClO3
Molecular Weight: 226.66
MDL number: MFCD00156903
EINECS: 610-810-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 23:03:12

What is 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID?

Chemical properties

White needle crystals. Melting point 82-83℃.

The Uses of 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID

4-(4-Chlorophenyl)-3-methyl-4-oxobutyric Acid is an intermediate of pimobendan.

Synthesis

Using 1-(α-bromopropionyl)-4-chlorobenzene and diethyl malonate to generate 2-carboxy-3-(4-chlorobenzoyl) butyric acid, which is heated and decarboxylated to obtain 4-(4-Chlorophenyl)-3-methyl-4-oxobutyric Acid.

Properties of 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID

Melting point:	82-83℃
Boiling point:	407.6±25.0 °C(Predicted)
Density	1.277
storage temp.	2-8°C
solubility	soluble in Methanol
form	powder to crystal
pka	4.46±0.19(Predicted)
color	White to Orange to Green
CAS DataBase Reference	52240-25-2

Safety information for 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID

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