4-chloro-7-Methoxyquinoline-6-carboxaMide
- CAS NO.：417721-36-9
- Empirical Formula: C11H9ClN2O2
- Molecular Weight: 236.65
- MDL number: MFCD13192256
- EINECS: 000-000-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-21 14:20:00
What is 4-chloro-7-Methoxyquinoline-6-carboxaMide?
Description
4-chloro-7-Methoxyquinoline-6-carboxaMide is a pharmaceutical intermediate compound used in the preparation of Lenvatinib, an oral multi-receptor tyrosine kinase inhibitor approved by the FDA for the treatment of radioiodine-refractory differentiated thyroid cancer (DTC), unresectable (DTC), unresectable hepatocellular carcinoma (HCC), and advanced renal cell carcinoma (RCC).
Chemical properties
light yellow powder
The Uses of 4-chloro-7-Methoxyquinoline-6-carboxaMide
Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.
Properties of 4-chloro-7-Methoxyquinoline-6-carboxaMide
| Melting point: | >205°C (dec.) |
| Boiling point: | 426.7±45.0 °C(Predicted) |
| Density | 1.380±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 15.28±0.30(Predicted) |
| color | Off-White to Light Beige |
| InChI | InChI=1S/C11H9ClN2O2/c1-16-10-5-9-6(4-7(10)11(13)15)8(12)2-3-14-9/h2-5H,1H3,(H2,13,15) |
| CAS DataBase Reference | 417721-36-9 |
Safety information for 4-chloro-7-Methoxyquinoline-6-carboxaMide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-chloro-7-Methoxyquinoline-6-carboxaMide
| InChIKey | ZBTVNIDMGKZSGC-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC(C(N)=O)=C(OC)C=2)C(Cl)=CC=1 |
4-chloro-7-Methoxyquinoline-6-carboxaMide manufacturer
LUPA PHARMACEUTICALS
1Y
Phone:+91-9059186565
Whatsapp: +91-9059186565
product: 4-Chloro-7-Methoxyquinoline-6-Carboxamide 417721-36-9 98+
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: 4-Chloro-7-methoxyquinoline-6-carboxamide
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