4-Amino-3-chlorophenol
- CAS NO.：17609-80-2
- Empirical Formula: C6H6ClNO
- Molecular Weight: 143.57
- MDL number: MFCD00801116
- EINECS: 241-583-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-02 17:37:48
What is 4-Amino-3-chlorophenol?
Chemical properties
Light yellow solid
The Uses of 4-Amino-3-chlorophenol
4-Amino-3-Chlorophenol acts as a synthetic reagent for the preparation of Benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer''s disease treatment.
What are the applications of Application
The 4-amino-3-chlorophenol is a crucial intermediate for preparing a tyrosine kinase inhibitor, tivozanib, and a late liver cancer drug, lenvatinib. As a crucial pharmaceutical chemical intermediate, 4-amino-3-chlorophenol is widely applied to the design and synthesis of medicaments for resisting tumors, cardiovascular diseases, neurological diseases, and the like.
Synthesis
Starting from o-chloronitrobenzene with introducing hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Besides, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling also could synthesize 4-Amino-3-chlorophenol.
Properties of 4-Amino-3-chlorophenol
| Melting point: | 159-160℃ |
| Boiling point: | 287.3±25.0 °C(Predicted) |
| Density | 1.406±0.06 g/cm3(Predicted) |
| RTECS | SJ5710000 |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.26±0.18(Predicted) |
| form | Crystalline Powder |
| color | White |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 17609-80-2(CAS DataBase Reference) |
Safety information for 4-Amino-3-chlorophenol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4-Amino-3-chlorophenol
4-Amino-3-chlorophenol manufacturer
SAKEM LLP
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