4-Amino-3-chlorophenol

CAS NO.：17609-80-2
Empirical Formula: C6H6ClNO
Molecular Weight: 143.57
MDL number: MFCD00801116
EINECS: 241-583-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 23:24:28

What is 4-Amino-3-chlorophenol?

Chemical properties

Light yellow solid

The Uses of 4-Amino-3-chlorophenol

4-Amino-3-Chlorophenol acts as a synthetic reagent for the preparation of Benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer''s disease treatment.

What are the applications of Application

The 4-amino-3-chlorophenol is a crucial intermediate for preparing a tyrosine kinase inhibitor, tivozanib, and a late liver cancer drug, lenvatinib. As a crucial pharmaceutical chemical intermediate, 4-amino-3-chlorophenol is widely applied to the design and synthesis of medicaments for resisting tumors, cardiovascular diseases, neurological diseases, and the like.

Synthesis

Starting from o-chloronitrobenzene with introducing hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Besides, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling also could synthesize 4-Amino-3-chlorophenol.

Properties of 4-Amino-3-chlorophenol

Melting point:	159-160℃
Boiling point:	287.3±25.0 °C(Predicted)
Density	1.406±0.06 g/cm3(Predicted)
RTECS	SJ5710000
storage temp.	2-8°C(protect from light)
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.26±0.18(Predicted)
form	Crystalline Powder
color	White
Stability:	Hygroscopic
CAS DataBase Reference	17609-80-2(CAS DataBase Reference)

Safety information for 4-Amino-3-chlorophenol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.