4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE

CAS NO.：62433-26-5
Empirical Formula: C13H8ClFO2
Molecular Weight: 250.65
MDL number: MFCD00040948
EINECS: 263-539-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:22:38

What is 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE?

The Uses of 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE

4''-Chloro-5-fluoro-2-hydroxybenzophenone is a metabolite of Progabide (P755350) which is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity. 4''-Chloro-5-fluoro-2-hydroxybenzophenone is also used as a reagent in the synthesis of a series of novel dihydrobenzofuranols which displayed antibacterial activity comparable to bacitracin, ciprofloxacin and gentamicin.

Preparation

Preparation by Fries rearrangement of p-fluorophenyl p-chlorobenzoate,
? with titanium tetrachloride at 150° for 18 h (81%);
? with aluminium chloride, at 130° for 2 h (98%) or at 200° for 5 min or for 15 min (65%).

Properties of 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE

Melting point:	65-69 °C(lit.)
Boiling point:	145-152/5mm
Density	1.376
Flash point:	177℃
storage temp.	2-8°C
form	powder to crystal
color	White to Yellow to Green
Water Solubility	8.999mg/L(37 ºC)
CAS DataBase Reference	62433-26-5(CAS DataBase Reference)

Safety information for 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.