4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
- CAS NO.：62433-26-5
- Empirical Formula: C13H8ClFO2
- Molecular Weight: 250.65
- MDL number: MFCD00040948
- EINECS: 263-539-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-14 15:27:00
What is 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE?
The Uses of 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
4''-Chloro-5-fluoro-2-hydroxybenzophenone is a metabolite of Progabide (P755350) which is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity. 4''-Chloro-5-fluoro-2-hydroxybenzophenone is also used as a reagent in the synthesis of a series of novel dihydrobenzofuranols which displayed antibacterial activity comparable to bacitracin, ciprofloxacin and gentamicin.
Preparation
Preparation by Fries rearrangement of p-fluorophenyl p-chlorobenzoate,
? with titanium tetrachloride at 150° for 18 h (81%);
? with aluminium chloride, at 130° for 2 h (98%) or at 200° for 5 min or for 15 min (65%).
Properties of 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
| Melting point: | 65-69 °C(lit.) |
| Boiling point: | 145-152/5mm |
| Density | 1.376 |
| Flash point: | 177℃ |
| storage temp. | 2-8°C |
| form | powder to crystal |
| color | White to Yellow to Green |
| Water Solubility | 8.999mg/L(37 ºC) |
| CAS DataBase Reference | 62433-26-5(CAS DataBase Reference) |
Safety information for 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
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