4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS NO.：327-78-6
Empirical Formula: C8H3ClF3NO
Molecular Weight: 221.56
MDL number: MFCD00013874
EINECS: 608-783-6;455-070-9
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-17 10:44:43

What is 4-Chloro-3-(trifluoromethyl)phenyl isocyanate?

Chemical properties

White solid or melt

The Uses of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate

4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of: N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea [1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea] trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea

The Uses of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate

4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of:

N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea
[1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea]
trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea

What are the applications of Application

4-Chloro-3-(trifluoromethyl)phenyl isocyanate is used to synthesize N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea

General Description

4-Chloro-3-(trifluoromethyl)phenyl isocyanate participates in an efficient methodology for the synthesis of 5-methyl-3-aryl-2-thiooxazolidin-4-ones.

Flammability and Explosibility

Non flammable

Properties of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Melting point:	40-42 °C(lit.)
Boiling point:	86-90 °C14 mm Hg(lit.)
Density	1.4720 (estimate)
vapor pressure	91Pa at 20℃
Flash point:	211 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Chloroform, Methanol
form	Low Melting Solid, Powder or Chunks
color	White to yellow
Sensitive	Moisture Sensitive
BRN	522032
InChI	InChI=1S/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H
CAS DataBase Reference	327-78-6(CAS DataBase Reference)

Safety information for 4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.