4-Chloro-3-nitroaniline

Synonym(s):4-Amino-1-chloro-2-nitrobenzene

CAS NO.：635-22-3
Empirical Formula: C6H5ClN2O2
Molecular Weight: 172.57
MDL number: MFCD00007844
EINECS: 211-231-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-04 16:00:12

What is 4-Chloro-3-nitroaniline ?

Chemical properties

ochre powder

The Uses of 4-Chloro-3-nitroaniline

Intermediate in the manufacture of azo dyes, pharmaceuticals, and other organic compounds.

What are the applications of Application

Commercial 4-chloro-3-nitroaniline could be used as a starting material for 3-azido-4-chlorophenylisothiocyanate through a 5-step synthesis. In order to research the impact of the strain on the metabolite profile of plasma samples in rats, 45 mg/kg bw/day 4-chloro-3-nitroaniline (4C3N) was evaluated for 4 weeks. 4C3N administration led to extravascular hemolytic anemia with a few metabolome changes, which were strain-dependent [1-2].

Hazard

Toxic by ingestion and inhalation.

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx and Cl-.

References

[1] H. Lamotte. “Synthesis of N‐(3‐azido‐4‐chlorophenyl)‐N′‐[3H‐methyl] thiourea, an efficient photoaffinity probe for the urea carrier.” Journal of Labelled Compounds and Radiopharmaceuticals 42 1 (1994): 289–295.
[2] O’Donoghue, John L. “Subchronic oral toxicology of 4-chloro-3-nitroaniline in the rat.” Fundamental and Applied Toxicology 6 3 (1986): Pages 551-558.

Properties of 4-Chloro-3-nitroaniline

Melting point:	99-101 °C (lit.)
Boiling point:	200°C (rough estimate)
Density	1.5610 (rough estimate)
refractive index	1.5870 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	1.87±0.10(Predicted)
color	White to Yellow to Orange
BRN	1309394
InChI	InChI=1S/C6H5ClN2O2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H,8H2
CAS DataBase Reference	635-22-3(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 4-chloro-3-nitro-(635-22-3)
EPA Substance Registry System	4-Chloro-3-nitroaniline (635-22-3)

Safety information for 4-Chloro-3-nitroaniline

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H300:Acute toxicity,oral H310:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H373:Specific target organ toxicity, repeated exposure H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P314:Get medical advice/attention if you feel unwell. P320:Specific treatment is urgent (see … on this label). P330:Rinse mouth. P391:Collect spillage. Hazardous to the aquatic environment P302+P350:IF ON SKIN: Gently wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…