4-BIPHENYLSULFONYL CHLORIDE
Synonym(s):(4-Biphenylyl)sulfonyl chloride;p-Biphenylsulfonyl chloride;p-Phenylbenzenesulfonyl chloride;4-(Chlorosulfonyl)biphenyl;4-Phenylbenzenesulfonic acid chloride
- CAS NO.：1623-93-4
- Empirical Formula: C12H9ClO2S
- Molecular Weight: 252.72
- MDL number: MFCD00078658
- EINECS: 216-609-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:52
What is 4-BIPHENYLSULFONYL CHLORIDE?
Chemical properties
White crystalline powder
The Uses of 4-BIPHENYLSULFONYL CHLORIDE
Reactant for:• ;Preparation of anilinopyrimidinesulfonamides as potential anticancer agents1• ;Synthesis of inhibitors of the hypoxia inducible factor pathway2• ;Preparation of hydroxy-sulfonyl-piperidinyl butyramides as HDAC inhibitors and potential antitumors3• ;Palladium-catalyzed desulfitative C-arylation4
The Uses of 4-BIPHENYLSULFONYL CHLORIDE
It is a reactant for preparation of anilinopyrimidinesulfonamides as potential anticancer agents, synthesis of inhibitors of the hypoxia inducible factor pathway. It participates in the preparation of hydroxy-sulfonyl-piperidinyl butyramides as HDAC inhibitors and potential antitumors and is also involved in palladium-catalyzed desulfitative C-arylation.
What are the applications of Application
Biphenyl-4-sulfonyl chloride is a potent HDAC inhibitor with catalytic applications
Properties of 4-BIPHENYLSULFONYL CHLORIDE
| Melting point: | 103-108 °C(lit.) |
| Boiling point: | 200-205°C 6mm |
| Density | 1.320±0.06 g/cm3(Predicted) |
| Flash point: | 200-205°C/6mm |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO: 50 mg/mL (197.85 mM);; |
| form | Crystalline Powder |
| color | White |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 2694373 |
| CAS DataBase Reference | 1623-93-4(CAS DataBase Reference) |
Safety information for 4-BIPHENYLSULFONYL CHLORIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-BIPHENYLSULFONYL CHLORIDE
| InChIKey | ALBQXDHCMLLQMB-UHFFFAOYSA-N |
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