4-Biphenylacetic acid

Synonym(s):4-Biphenylacetic acid

CAS NO.：5728-52-9
Empirical Formula: C14H12O2
Molecular Weight: 212.24
MDL number: MFCD00004351
EINECS: 227-233-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 14:33:18

What is 4-Biphenylacetic acid?

Description

Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.

Chemical properties

Off-white powder

Originator

Lederle (USA)

The Uses of 4-Biphenylacetic acid

4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.

The Uses of 4-Biphenylacetic acid

Anti-inflammatory, analgesic drug.

What are the applications of Application

4-Biphenylacetic acid is a potential non-steroidal antiinflammatory drug

Definition

ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.

brand name

Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).

General Description

4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.

Safety Profile

Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.

Properties of 4-Biphenylacetic acid

Melting point:	159-160 °C (lit.)
Boiling point:	312.08°C (rough estimate)
Density	1.1035 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	DMSO: soluble50mg/mL, clear, colorless to yellow
pka	4.29±0.10(Predicted)
form	Powder
color	Beige
Water Solubility	39.27mg/L(25 ºC)
Merck	14,3316
BRN	1211592
InChI	InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
CAS DataBase Reference	5728-52-9(CAS DataBase Reference)

Safety information for 4-Biphenylacetic acid

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.