4-Aminophenyl-1-phenethylpiperidine

Synonym(s):N-[1-(2-Phenylethyl)-4-piperidinyl]aniline;N-Phenyl-1-(2-phenylethyl)-4-piperidinamine;Despropionylfentanyl

CAS NO.：21409-26-7
Empirical Formula: C19H24N2
Molecular Weight: 280.41
MDL number: MFCD00179023
SAFETY DATA SHEET (SDS)
Update Date: 2026-11-04 17:03:59

4-Aminophenyl-1-phenethylpiperidine Structural

What is 4-Aminophenyl-1-phenethylpiperidine?

Description

4-ANPP (Item No. 18810) is an analytical reference material categorized as an opioid metabolite and a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 22659 | 14719) and other opioids. 4-ANPP is a metabolite of acetyl fentanyl (Item Nos. ISO60128 | ISO00128), butyryl fentanyl (Item Nos. 19734 | 14728), furanyl fentanyl (Item Nos. 19633 | 18705), acrylfentanyl (Item Nos. 23060 | 19312), and fentanyl. It has also been found as an impurity in illicit fentanyl preparations. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Description

4-ANPP (CRM) (Item No. 22700) is a certified reference material that is categorized as a piperidinamine. It is an intermediate in the synthesis of fentanyl (Item Nos. 22659 | 14719 | ISO60197) from N-phenethyl-4-piperidone (NPP; ). As such, 4-ANPP has been used as a precursor for the manufacture of fentanyl and related opioids. 4-ANPP is also an impurity found in fentanyl preparations. It is a known metabolite of acetyl fentanyl (Item Nos. ISO00128 | ISO60128), butyryl fentanyl (Item Nos. 14728 | 19734), furanyl fentanyl (Item Nos. 18705 | 19633), acrylfentanyl , and fentanyl. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Chemical properties

Pale Yellow Solid

The Uses of 4-Aminophenyl-1-phenethylpiperidine

A 3H-Fentanyl (F274990) metabolite

Properties of 4-Aminophenyl-1-phenethylpiperidine

Melting point:	94-96°C
Boiling point:	172-176 °C(Press: 0.15 Torr)
Density	1.075±0.06 g/cm3(Predicted)
Flash point:	9°C
storage temp.	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
form	Off-white solid.
pka	9.03±0.10(Predicted)

Safety information for 4-Aminophenyl-1-phenethylpiperidine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection.