4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
Synonym(s):N-[1-(2-Phenylethyl)-4-piperidinyl]aniline;N-Phenyl-1-(2-phenylethyl)-4-piperidinamine;Despropionylfentanyl
- CAS NO.:21409-26-7
- Empirical Formula: C19H24N2
- Molecular Weight: 280.41
- MDL number: MFCD00179023
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:18:55
What is 4-AMINOPHENYL-1-PHENETHYLPIPERIDINE?
Description
4-ANPP (Item No. 18810) is an analytical reference material categorized as an opioid metabolite and a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 22659 | 14719) and other opioids. 4-ANPP is a metabolite of acetyl fentanyl (Item Nos. ISO60128 | ISO00128), butyryl fentanyl (Item Nos. 19734 | 14728), furanyl fentanyl (Item Nos. 19633 | 18705), acrylfentanyl (Item Nos. 23060 | 19312), and fentanyl. It has also been found as an impurity in illicit fentanyl preparations. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Description
4-ANPP (CRM) (Item No. 22700) is a certified reference material that is categorized as a piperidinamine. It is an intermediate in the synthesis of fentanyl (Item Nos. 22659 | 14719 | ISO60197) from N-phenethyl-4-piperidone (NPP; ). As such, 4-ANPP has been used as a precursor for the manufacture of fentanyl and related opioids. 4-ANPP is also an impurity found in fentanyl preparations. It is a known metabolite of acetyl fentanyl (Item Nos. ISO00128 | ISO60128), butyryl fentanyl (Item Nos. 14728 | 19734), furanyl fentanyl (Item Nos. 18705 | 19633), acrylfentanyl , and fentanyl. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Chemical properties
Pale Yellow Solid
The Uses of 4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
A 3H-Fentanyl (F274990) metabolite
Properties of 4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
| Melting point: | 94-96°C |
| Boiling point: | 172-176 °C(Press: 0.15 Torr) |
| Density | 1.075±0.06 g/cm3(Predicted) |
| Flash point: | 9°C |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| form | Off-white solid. |
| pka | 9.03±0.10(Predicted) |
Safety information for 4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
| Signal word | Danger |
| Pictogram(s) |
![]() Skull and Crossbones Acute Toxicity GHS06 |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate 3,6-Dichloropyridazine Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane 4-Morpholinoaniline 2-Chloromethyl-6-methyl-pyridine 1-Indanone tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 2-Pyridinecarboxaldehdye 6-Methyl-2-pyridinemethanol 4-Bromo-2-fluoro-N-methylbenzamide 3-Azetidinecarboxylic acid N-(2-(4-((4-Fluorobenzyl)carbamoyl)-5-hydroxy-6-methoxypyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide (R)-4-Boc-morpholine-3-carboxylic acid (Required high chiral purity NLT:99.5%) Tetrahydro-3-(2-methyl-2- nitropropyl)-2H-pyran-2-one 3-Bromo-2-fluorobenzonitrile Desoximetasone Boron Triiodide Nicotinic acid RAPAMYCIN Pentachlorobenzonitrile BudesonideRelated products of tetrahydrofuran


![N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]BENZAMIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB5112056.gif)


![N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]CYCLOPROPYLCARBOXAMIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB2116538.gif)
![4-PIPERIDINECARBOXYLIC ACID, 4-[(1-OXOPROPYL)PHENYLAMINO]](https://img.chemicalbook.in/CAS/GIF/186022-53-7.gif)
![4-PIPERIDINECARBOXYLIC ACID, 4-[(1-OXOPROPYL)PHENYLAMINO]-1-(2-PHENYLETHYL), METHYL ESTER ETHANEDIOATE](https://img.chemicalbook.in/StructureFile/ChemBookStructure4/GIF/CB7295706.gif)
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