4-Aminoguinoline
- CAS NO.：578-68-7
- Empirical Formula: C9H8N2
- Molecular Weight: 144.17
- MDL number: MFCD00463448
- EINECS: 640-116-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:24:10
What is 4-Aminoguinoline?
Chemical properties
Light brown to grey solid
The Uses of 4-Aminoguinoline
4-Quinolinamine and its derivatives are commonly used as anti-malarial drugs and also have potential therapeutic effects on patients afflicted with arthritis (and/or related diseases).
What are the applications of Application
4-Aminoquinoline is a variety of derivatives of 4-aminoquinoline are antimalarial agents
Synthesis Reference(s)
Journal of Medicinal Chemistry, 43, p. 4667, 2000 DOI: 10.1021/jm0002073
Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2
Purification Methods
It has been purified by zone refining and recrystallisation from *C6H6, EtOH or H2O. The hydrochloride has m 308o (from MeOH), and the picrate has m 277o (from EtOH). [Albert et al. J Chem Soc 2240 1948, Beilstein 22 III/IV 4611, 22/10 V 341.]
Properties of 4-Aminoguinoline
| Melting point: | 151.0 and le 155.0 °C |
| Boiling point: | 312.78°C (estimate) |
| Density | 1.1148 (estimate) |
| refractive index | 1.7080 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 9.17(at 20℃) |
| form | powder to crystalline |
| color | White to Yellow to Orange |
| CAS DataBase Reference | 578-68-7(CAS DataBase Reference) |
Safety information for 4-Aminoguinoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 4-Aminoguinoline
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