6-Aminoquinoline
Synonym(s):6-Quinolinamine
- CAS NO.：580-15-4
- Empirical Formula: C9H8N2
- Molecular Weight: 144.17
- MDL number: MFCD00006803
- EINECS: 209-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:44
What is 6-Aminoquinoline?
Chemical properties
Dark yellow to brown crystalline powder
The Uses of 6-Aminoquinoline
6-Aminoquinoline is used in the preparation of diaminopyrimidine derivatives as 5-HT4 receptor agonists.
The Uses of 6-Aminoquinoline
6-Aminoquinoline was used as an internal standard in determining serum nicotine and cotinine simultaneously by using high-performance liquid chromatography (HPLC)-fluorometric detection with a postcolumn ultraviolet-photoirradiation system. It was also used as a fluorescent derivatizing agent for the detection of biochemicals and in the synthesis of tertiary N-methylated enaminonesa.
Purification Methods
It is purified by column chromatography on a SiO2 column using CHCl3/MeOH (4:1) as eluent. It crystallises from *C6H6 or *C6H6/pet ether and is an irritant. The styphnate has m 239-240o (from EtOH) and m 242-243o (from aqueous Me2CO). [Barrett et al. J Chem Soc 50, 57 1953, Beilstein 22 III/IV 4681, 22/10 V 303.]
Properties of 6-Aminoquinoline
| Melting point: | 115-119 °C (lit.) |
| Boiling point: | 146 °C/0.3 mmHg (lit.) |
| Density | 1.1148 (estimate) |
| refractive index | 1.7080 (estimate) |
| Flash point: | 146°C/0.3mm |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, DMSO, Methanol |
| form | Solid |
| pka | pK1: 5.63(+1) (20°C,μ=0.01) |
| color | Pale Brown to Brown |
| Water Solubility | Soluble in methanol, chloroform, ethanol, and benzene. Insoluble in water. |
| Sensitive | Air Sensitive |
| BRN | 113320 |
| CAS DataBase Reference | 580-15-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 6-Quinolinamine(580-15-4) |
Safety information for 6-Aminoquinoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 6-Aminoquinoline
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