6-Aminoquinoline

Synonym(s):6-Quinolinamine

CAS NO.：580-15-4
Empirical Formula: C9H8N2
Molecular Weight: 144.17
MDL number: MFCD00006803
EINECS: 209-453-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:45:22

What is 6-Aminoquinoline?

Chemical properties

Dark yellow to brown crystalline powder

The Uses of 6-Aminoquinoline

6-Aminoquinoline is used in the preparation of diaminopyrimidine derivatives as 5-HT4 receptor agonists.

The Uses of 6-Aminoquinoline

6-Aminoquinoline was used as an internal standard in determining serum nicotine and cotinine simultaneously by using high-performance liquid chromatography (HPLC)-fluorometric detection with a postcolumn ultraviolet-photoirradiation system. It was also used as a fluorescent derivatizing agent for the detection of biochemicals and in the synthesis of tertiary N-methylated enaminonesa.

Purification Methods

It is purified by column chromatography on a SiO2 column using CHCl3/MeOH (4:1) as eluent. It crystallises from *C6H6 or *C6H6/pet ether and is an irritant. The styphnate has m 239-240o (from EtOH) and m 242-243o (from aqueous Me2CO). [Barrett et al. J Chem Soc 50, 57 1953, Beilstein 22 III/IV 4681, 22/10 V 303.]

Properties of 6-Aminoquinoline

Melting point:	115-119 °C (lit.)
Boiling point:	146 °C/0.3 mmHg (lit.)
Density	1.1148 (estimate)
refractive index	1.7080 (estimate)
Flash point:	146°C/0.3mm
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform, DMSO, Methanol
form	Solid
pka	pK1: 5.63(+1) (20°C,μ=0.01)
color	Pale Brown to Brown
Water Solubility	Soluble in methanol, chloroform, ethanol, and benzene. Insoluble in water.
Sensitive	Air Sensitive
BRN	113320
CAS DataBase Reference	580-15-4(CAS DataBase Reference)
NIST Chemistry Reference	6-Quinolinamine(580-15-4)

Safety information for 6-Aminoquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.