4-Amino-5-aminomethyl-2-methylpyrimidine

Chemical properties

Off-White Solid

The Uses of 4-Amino-5-aminomethyl-2-methylpyrimidine

Substrate for TenA enzyme in the thiamin salvage pathway

What are the applications of Application

4-Amino-5-aminomethyl-2-methylpyrimidine is A substrate for the enzyme TenA in the thiamin salvage pathway

Definition

ChEBI: An aminopyrimidine compound having its amino substituent at the 4-position together with methyl and aminomethyl substituents at the 2- and 5-positions respectively.

Synthesis

In an autoclave, the mixture of 4-Amino-5-aminomethyl-2-methylpyrimidine (2.0 kg, 15 mol), modified Raney nickel (wet weight 300 g), and saturated methanol solution of ammonia (20 L) was heated to 100 ℃ and stirred for 5 h at this temperature under 4 MPa hydrogen pressure. Then, the mixture was cooled to room temperature and filtered; 4-Amino-5-aminomethyl-2-methyl pyrimidine was obtained as a white solid (2.0 kg, 98%) by concentrating the filtrate[1].

References

[1] Lei Zhao, Fen-Er Chen, Xiao-Dong Ma. “Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1.” Organic Process Research & Development 16 1 (2011): 57–60.