4-AMINO-2-MERCAPTOPYRIMIDINE

Synonym(s):4-Amino-2-mercaptopyrimidine;4-Amino-2-thiopyrimidine

CAS NO.：333-49-3
Empirical Formula: C4H5N3S
Molecular Weight: 127.17
MDL number: MFCD00057341
EINECS: 206-374-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:23:37

What is 4-AMINO-2-MERCAPTOPYRIMIDINE?

Chemical properties

Beige toYellow Powder

The Uses of 4-AMINO-2-MERCAPTOPYRIMIDINE

This compound has been shown to inhibit iodothyronine 5’-deiodinase, the enzyme responsible for the 5’-deiodination of thyroxine in human liver cells.

The Uses of 4-AMINO-2-MERCAPTOPYRIMIDINE

2-Thiocytosine has been used to investigate the reactions involved in hole transfer (HT) in X-irradiated doped cytosine monohydrate.

General Description

2-Thiocytosine is a potential antileukemic and anticancer agent. 2-Thiocytosine in solid state has been investigated by (1)H-(14)N NMR-NQR double resonance (NQDR) spectroscopy and theoretically by the quantum theory of atoms in molecules (QTAIM)/density functional theory (DFT).

Purification Methods

It is recrystallised from hot H2O and dried at 100o to constant weight. [Brown J Appl Chem (London) 9 203 1959, Russell et al. J Am Chem Soc 71 2279 1949.] It is used in transcription and translation studies [Rachwitz & Scheit Eur J Biochem 72 191 1977].

Properties of 4-AMINO-2-MERCAPTOPYRIMIDINE

Melting point:	285-290 °C (dec.)(lit.)
Boiling point:	232.1±43.0 °C(Predicted)
Density	1.313 (estimate)
refractive index	1.5800 (estimate)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Water (Slightly)
form	Powder
pka	7.91±0.10(Predicted)
color	Yellow
BRN	112435
CAS DataBase Reference	333-49-3(CAS DataBase Reference)
EPA Substance Registry System	2(1H)-Pyrimidinethione, 4-amino- (333-49-3)

Safety information for 4-AMINO-2-MERCAPTOPYRIMIDINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.