AT-56
Synonym(s):4-Dibenzo[a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine
- CAS NO.：162640-98-4
- Empirical Formula: C25H27N5
- Molecular Weight: 397.52
- MDL number: MFCD18086874
- EINECS: 200-256-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-14 16:49:18
What is AT-56?
The Uses of AT-56
AT-56 is an orally active inhibitor of Lipocalin-type prostaglandin D synthase.
What are the applications of Application
AT-56 is AT-56 is a prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2.
in vitro
AT-56 (1-30 μM; 10 minutes) dose-dependently inhibits the production of PGD2 in L-PGDS-expressing human medulloblastoma TE-671 cells with an IC50 of about 3 μM.
in vivo
AT-56 (1-30 mg/kg; p.o.) suppresses the PGD2 production in the stab-wounded brain.
AT-56 (1-10 mg/kg; p.o.) suppresses the L-PGDS-mediated allergic airway inflammation in mice.
AT-56 (10 mg/kg; p.o.) exhibits Cmax (2.15 μg/ml), half-life (1.71 h) and high oral bioavailability (82%).
Storage
Store at -20°C
Properties of AT-56
| Boiling point: | 620.4±65.0 °C(Predicted) |
| Density | 1.216±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| pka | 4.99±0.10(Predicted) |
| color | white to beige |
Safety information for AT-56
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H228:Flammable solids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. |
Computed Descriptors for AT-56
| InChIKey | LQNGMDUIRLSESZ-UHFFFAOYSA-N |
| SMILES | N1(CCCCC2=NNN=N2)CC/C(=C2/C3=CC=CC=C3C=CC3=CC=CC=C3/2)/CC1 |
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