4-(4-Aminophenoxy)-N-methylpicolinamide
- CAS NO.：284462-37-9
- Empirical Formula: C13H13N3O2
- Molecular Weight: 243.26
- MDL number: MFCD08692047
- EINECS: 608-211-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:12:01
What is 4-(4-Aminophenoxy)-N-methylpicolinamide?
Chemical properties
Light-Brown Solid
The Uses of 4-(4-Aminophenoxy)-N-methylpicolinamide
Sorafenib intermediate
Synthesis
To a solution of 4-aminophenol (1 g, 9.2 mmol) in DMF (20 mL) was added 1M potassium ier/-butoxide in THF (9.7 mL, 9.7 mmol) at room temperature. After 2h, (4-chloro(2-pyridyl))-N- methyl carboxamide (1.6 g, 9.2 mmol) and potassium carbonate (0.64 g, 4.6 mmol) were added, and then the reaction mixture was heated to 80 °C for 6h. After cooling, the reaction mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with brine (20 mL) and dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography to afford 4-(4-Aminophenoxy)-N-methylpicolinamide (2.2 g, 80 %) as a light-brown solid.
Properties of 4-(4-Aminophenoxy)-N-methylpicolinamide
| Melting point: | 110-112°C |
| Boiling point: | 476.8±40.0 °C(Predicted) |
| Density | 1.241±0.06 g/cm3(Predicted) |
| vapor pressure | 0.001-0.05Pa at 20-109.84℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 13.96±0.46(Predicted) |
| form | Notspecified |
| color | White to Light yellow to Light orange |
Safety information for 4-(4-Aminophenoxy)-N-methylpicolinamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 4-(4-Aminophenoxy)-N-methylpicolinamide
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