4-Chloro-N-methylpicolinamide

CAS NO.：220000-87-3
Empirical Formula: C7H7ClN2O
Molecular Weight: 170.6
MDL number: MFCD02185921
EINECS: 606-888-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-28 09:12:15

What is 4-Chloro-N-methylpicolinamide?

Description

4-Chloro-N-methylpicolinamide is a polar organic compound that interacts with hydrogen bonds. It has been shown to inhibit the value-added of cancer cells by inhibiting protein synthesis to inhibit the growth of human hepatocellular carcinoma cells, bcr/abl kinase, and hct116 cells, and is a candidate for cancer treatment. Studies have shown that it also inhibits the proliferation of MDA-MB231 breast cancer cells by blocking growth factor activity. In addition, 4-Chloro-N-methylpicolinamide is a pharmaceutical intermediate component used in the preparation of the antineoplastic drugs regorafenib and sorafenib.

Chemical properties

Pale-Yellow Solid

The Uses of 4-Chloro-N-methylpicolinamide

4-Chloro-N-methylpyridine-2-carboxamide (>90%) (cas# 220000-87-3) is a compound useful in organic synthesis.

Hazard

4-Chloro-N-methylpicolinamide has acute toxic effects and is an eye and skin irritant.

Properties of 4-Chloro-N-methylpicolinamide

Melting point:	41-43°C
Boiling point:	317.8±27.0 °C(Predicted)
Density	1.264±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Met
form	Solid
pka	13.41±0.46(Predicted)
color	Off-White to Light Yellow Low-Melting
CAS DataBase Reference	220000-87-3(CAS DataBase Reference)

Safety information for 4-Chloro-N-methylpicolinamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.