4-Chloro-N-methylpicolinamide
- CAS NO.：220000-87-3
- Empirical Formula: C7H7ClN2O
- Molecular Weight: 170.6
- MDL number: MFCD02185921
- EINECS: 606-888-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:20:38
What is 4-Chloro-N-methylpicolinamide?
Description
4-Chloro-N-methylpicolinamide is a polar organic compound that interacts with hydrogen bonds. It has been shown to inhibit the value-added of cancer cells by inhibiting protein synthesis to inhibit the growth of human hepatocellular carcinoma cells, bcr/abl kinase, and hct116 cells, and is a candidate for cancer treatment. Studies have shown that it also inhibits the proliferation of MDA-MB231 breast cancer cells by blocking growth factor activity. In addition, 4-Chloro-N-methylpicolinamide is a pharmaceutical intermediate component used in the preparation of the antineoplastic drugs regorafenib and sorafenib.
Chemical properties
Pale-Yellow Solid
The Uses of 4-Chloro-N-methylpicolinamide
4-Chloro-N-methylpyridine-2-carboxamide (>90%) (cas# 220000-87-3) is a compound useful in organic synthesis.
Hazard
4-Chloro-N-methylpicolinamide has acute toxic effects and is an eye and skin irritant.
Properties of 4-Chloro-N-methylpicolinamide
| Melting point: | 41-43°C |
| Boiling point: | 317.8±27.0 °C(Predicted) |
| Density | 1.264±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Met |
| form | Solid |
| pka | 13.41±0.46(Predicted) |
| color | Off-White to Light Yellow Low-Melting |
| CAS DataBase Reference | 220000-87-3(CAS DataBase Reference) |
Safety information for 4-Chloro-N-methylpicolinamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4-Chloro-N-methylpicolinamide
4-Chloro-N-methylpicolinamide manufacturer
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: N-Methyl 4-chloro-pyridine-2-carboxamide
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