3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
Synonym(s):3′,5′-Cyclic-nucleotide 5′-nucleotidohydrolase from bovine brain;3′,5′-Cyclic-nucleotide 5′-nucleotidohydrolase from bovine heart;PDE
- CAS NO.：9040-59-9
- Molecular Weight: 0
- MDL number: MFCD00131864
- EINECS: 232-920-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:15:51
What is 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE?
The Uses of 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
For use in calmodulin (P 0270) assay. Activity is reduced to <50% without calmodulin present.
The Uses of 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain has been used to assay the protein activator, calmodulin and in in vitro adenylate cyclase assay.
General Description
Phosphodiesterase (PDE1) exists in two isoforms -PDE1A2 and PDE1B1. The enzyme has a role in the complex interaction between cyclic nucleotides and Ca2+ second-messenger systems.
Biochem/physiol Actions
Hydrolyzes the 3′,5′-phosphodiester bond in cyclic nucleotide monophosphates, such as cAMP and cGMP, to the corresponding nucleotide 5′-monophosphate.
Clinical Use
Phosphodiesterase-3 (PDE3) is an enzyme responsible for degradation of cAMP to AMP in platelets and blood vessels. Selective cAMP PDE3 inhibitors, such as dipyridamole and cilostazol , inhibit the degradation of cAMP, thereby increasing cellular concentration of cAMP and leading to inhibition of platelet aggregation and vasodilation.
Properties of 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
| storage temp. | -20°C |
| form | lyophilized powder |
Safety information for 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
Computed Descriptors for 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
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