3,4-Methylenedioxy-beta-nitrostyrene
Synonym(s):3,4-Methylenedioxy-β-nitrostyrene;Syk Inhibitor III - CAS 1485-00-3 - Calbiochem
- CAS NO.：1485-00-3
- Empirical Formula: C9H7NO4
- Molecular Weight: 193.16
- MDL number: MFCD00014575
- EINECS: 622-830-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:14:02
What is 3,4-Methylenedioxy-beta-nitrostyrene?
Description
MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.
Chemical properties
yellow powder
The Uses of 3,4-Methylenedioxy-beta-nitrostyrene
MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.
What are the applications of Application
MNS is a selective inhibitor of Syk kinase activity
Biological Activity
Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.
References
1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system; J. Biol. Chem., 286 16546
Properties of 3,4-Methylenedioxy-beta-nitrostyrene
| Melting point: | 159-163 °C |
| Boiling point: | 329.36°C (rough estimate) |
| Density | 1.4058 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml). |
| form | Yellow to brown solid |
| color | Yellow |
| Sensitive | Light Sensitive |
| BRN | 192350 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2 |
| CAS DataBase Reference | 1485-00-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3) |
Safety information for 3,4-Methylenedioxy-beta-nitrostyrene
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 3,4-Methylenedioxy-beta-nitrostyrene
| InChIKey | KFLWBZPSJQPRDD-UHFFFAOYSA-N |
| SMILES | O1C2=CC=C(C=C[N+]([O-])=O)C=C2OC1 |
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