3,4-DIHYDROISOQUINOLINE
- CAS NO.：3230-65-7
- Empirical Formula: C9H9N
- Molecular Weight: 131.17
- MDL number: MFCD00033714
- EINECS: 221-769-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:07
What is 3,4-DIHYDROISOQUINOLINE?
The Uses of 3,4-DIHYDROISOQUINOLINE
3,4-Dihydroisoquinoline is derived from 1,2,3,4-Tetrahydroisoquinoline (T293820), which is used as a reagent in the preparation of 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides as antiproliferative tubulin inhibitors.
The Uses of 3,4-DIHYDROISOQUINOLINE
3,4-Dihydroisoquinoline can be used as a reactant to synthesize:
- 5,6-Dihydro-8H-isoquino[1,2-b]quinazolin-8-one by decarboxylative cyclization reaction with isatoic anhydride using tetrabutylammonium iodide (TBAI).
- 1-naphtholyl tetrahydroisoquinoline by aza-Friedel-Crafts reaction with various naphthols.
- 3,4-dihydroisoquinoline pseudo bases, which are employed as starting materials for the preperation of 3-benzazepine derivatives.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 6567, 1994 DOI: 10.1016/S0040-4039(00)78274-8
Properties of 3,4-DIHYDROISOQUINOLINE
| Melting point: | 251-254℃ |
| Boiling point: | 241.8±20.0℃ (760 Torr) |
| Density | 1.05±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.6041 (589.3 nm 30℃) |
| Flash point: | 91.6±22.6℃ |
| storage temp. | 2-8°C |
| pka | 5.80±0.20(Predicted) |
Safety information for 3,4-DIHYDROISOQUINOLINE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H310:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3,4-DIHYDROISOQUINOLINE
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