3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

Synonym(s):3,4-Dichloro-N-(1-methylbutyl)-benzamide;3,4-Dichloro-N-(pentan-2-yl)benzamide;NSC 405020

CAS NO.：7497-07-6
Empirical Formula: C12H15Cl2NO
Molecular Weight: 260.16
MDL number: MFCD02006898
EINECS: 804-136-9
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-10 09:00:29

3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Structural

What is 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide?

Description

NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3

The Uses of 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

NSC 405020 is a novel, selective, and noncatalytic membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor that directly interacts with the homopexin (PEX) domain of MT1-MMP.

Storage

Store at RT

References

1) Remacle?et al.?(2012),?Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth;? Cancer Res.,?72?2339 2) Kittaka?et al.?(2018)?Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts?; J. Bone Miner. Res.,?33?167 3) Thang?et al.?(2014)?Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma; PLoS One,?9(5)?e96945

Properties of 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

Boiling point:	353.7±32.0 °C(Predicted)
Density	1.182±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka	13.38±0.46(Predicted)
form	powder
color	white to beige
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety information for 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.