3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
Synonym(s):4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetic acid;Tetrac
- CAS NO.：67-30-1
- Empirical Formula: C14H8I4O4
- Molecular Weight: 747.83
- MDL number: MFCD00055932
- EINECS: 200-649-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-21 16:49:52
What is 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID?
The Uses of 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
Thyroid hormone analogue
The Uses of 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
3,3′,5,5′-Tetraiodothyroacetic acid has been used:
- as a positive control to study the effects of ioxynil (IOX)
- diethylstilbestrol (DES) exposure on zebrafish embryos
- to study its effects on long-term potentiation (LTP) and long-term depression (LTD) in the dentate gyrus in urethane-anesthetized male rats
- to determine its influence on the actions of thyroid-stimulating hormone
- thyroid-stimulating immunoglobulins in orbital fibroblast
Definition
ChEBI: A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.
Biochem/physiol Actions
Studies in rats have reported that Tetrac may regulate TSH secretion under in vivo conditions1.
Properties of 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
| Melting point: | 219-220 °C (decomp) |
| Boiling point: | 544.8±50.0 °C(Predicted) |
| Density | 2.727±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly yellow to yellow) |
| form | powder to crystal |
| pka | 3.98±0.10(Predicted) |
| color | White to Yellow to Green |
Safety information for 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H300:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
| InChIKey | PPJYSSNKSXAVDB-UHFFFAOYSA-N |
3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID manufacturer
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