3,3,5-Trimethylcyclohexanol
Synonym(s):3,3,5-Trimethylcyclohexanol;Homomenthol, Dihydroisophorol
- CAS NO.：116-02-9
- Empirical Formula: C9H18O
- Molecular Weight: 142.24
- MDL number: MFCD00019378
- EINECS: 204-122-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:04
What is 3,3,5-Trimethylcyclohexanol?
Chemical properties
WHITE CRYSTALLINE MASS. Soluble in most organic solvents, hydrocarbons, oils; insoluble in water. Combustible.
Chemical properties
3,3,5-Trimethyl cyclohexanol has a menthol-like camphorous odor.
Occurrence
Has apparently not been reported to occur in nature.
The Uses of 3,3,5-Trimethylcyclohexanol
Menthol and camphor substitute, antifoaming agent, hydraulic fluids and textile soaps, odor masking, esterification agent, pharmaceuticals,wax additive, printing inks.
Definition
ChEBI: A secondary alcohol that is cyclohexanol substituted by two methyl groups at the 3-position and one methyl group at the 5-position. It exhibits inhibitory activity against HMG-CoA reductase ( EC 1.1.1.34/EC 1.1.1.88).
Preparation
By complete hydrogenation of isophorone (Arctander, 1969).
Synthesis Reference(s)
Tetrahedron, 37, p. 1171, 1981 DOI: 10.1016/S0040-4020(01)92046-0
Hazard
Toxic by inhalation, strong irritant.
Synthesis
Trimethyl cyclohexanol is synthesized by complete hydrogenation of isoPhorone. Dehydration of the title material with Zinc chloride yields alpha-Cyclogeraniolene.
Properties of 3,3,5-Trimethylcyclohexanol
| Melting point: | 30-32 °C |
| Boiling point: | 193-196 °C |
| Density | 0.86 |
| vapor pressure | 1 hPa (50 °C) |
| refractive index | 1.4559 (estimate) |
| FEMA | 3962 | 3,5,5-TRIMETHYLCYCLOHEXANOL |
| Flash point: | 81 °C |
| storage temp. | Store below +30°C. |
| form | powder to lump to clear liquid |
| pka | 15.35±0.60(Predicted) |
| color | A translucent, colourless, fused mass or crystals with a powerful menthol-like odour |
| PH | 7 (1.8g/l, H2O, 20°C) |
| Odor | at 100.00 %. mint cool mentholic musty spicy |
| explosive limit | 1.5%(V) |
| Water Solubility | 1.8 g/L (20 ºC) |
| JECFA Number | 1099 |
| CAS DataBase Reference | 116-02-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Cyclohexanol, 3,3,5-trimethyl-(116-02-9) |
| EPA Substance Registry System | Cyclohexanol, 3,3,5-trimethyl- (116-02-9) |
Safety information for 3,3,5-Trimethylcyclohexanol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. |
Computed Descriptors for 3,3,5-Trimethylcyclohexanol
New Products
Cyclopentane-1,2-dione 2,6-Dibromoaniline (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 1-AMino-cyclobutaneMethanol HCl TETRABUTYLAMMONIUM CYANIDE 3-Amino-3-(3-fluorophenyl)propanoic acid 3-Amino-3-(4-methylphenyl)propionic acid 3-AMINO-3-(3-CHLORO-PHENYL)-PROPIONIC ACID Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 4 - fluoro- 2 - methoxy- 5 - nitroaniline 1-(2-amino-5-hydroxy phenyl)propan-1-one tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-amino-5-nitrobenzonitrile (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 2-Chloro Benzylcyanide 3,4 Diethoxy Benzylcyanide 3,4 Dimethoxy Benzylcyanide 3-chlorobenzyl cyanideRelated products of tetrahydrofuran
You may like
-
116-02-9 3,3,5 -Trimethyl cyclohexanol 99%View Details
116-02-9 -
116-02-9 99%View Details
116-02-9 -
3,3,5 -Trimethyl cyclohexanol 99%View Details
116-02-9 -
3,3,5 -Trimethyl cyclohexanol 116-02-9 99%View Details
116-02-9 -
cis-3,3,5-Trimethylcyclohexanol (contains ca. 6 % trans- isomer) 90% (GC) CAS 116-02-9View Details
116-02-9 -
cis-3,3,5-Trimethylcyclohexanol (contains ca. 20% trans- isomer) CAS 116-02-9View Details
116-02-9 -
3,3,5-Trimethylcyclohexanol (cis- and trans- mixture) CAS 116-02-9View Details
116-02-9 -
Industrial Grade Liquid 3,3,5-Trimethylcyclohexanol, Packaging Size: 35 KgsView Details
116-02-9
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.