3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

Description

DSP Crosslinker is a cleavable crosslinker. It contains two terminal NHS ester moieties which can react with primary amines. The disulfide bonds can be cleaved via a reduction reaction using Dithiothreitol (DTT) reagent.

Chemical properties

Off-White Solid

The Uses of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used in the crosslinking of intracellular proteins prior to cell lysis.

The Uses of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used as amine reactive homobifunctional cross-linking reagent, cleavable under mild conditions with hydroxylamine (pH 8.5, 3-6 h, 37oC)

The Uses of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) has been used as a protein cross-linker.

What are the applications of Application

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) is a cleavable disulfide linkage-containing homobifunctional cross-linking reagent

General Description

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) is a homobifunctional cross-linking reagent containing a cleavable disulfide linkage. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5).