3-TRIMETHYLSILYL-2-PROPYN-1-OL
Synonym(s):3-(Trimethylsilyl)-2-propyn-1-ol
- CAS NO.：5272-36-6
- Empirical Formula: C6H12OSi
- Molecular Weight: 128.24
- MDL number: MFCD00002913
- EINECS: 226-094-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:17:11
What is 3-TRIMETHYLSILYL-2-PROPYN-1-OL?
Chemical properties
clear yellow liquid
The Uses of 3-TRIMETHYLSILYL-2-PROPYN-1-OL
Trimethylsilylpropargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.
Properties of 3-TRIMETHYLSILYL-2-PROPYN-1-OL
| Melting point: | 63.5-65.0 °C |
| Boiling point: | 76 °C11 mm Hg(lit.) |
| Density | 0.865 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 152 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Benzene (Sparingly) |
| form | Liquid |
| pka | 13.71±0.10(Predicted) |
| color | Clear yellow |
| Specific Gravity | 0.865 |
| Water Solubility | Not miscible with water. |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 1902505 |
| CAS DataBase Reference | 5272-36-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Trimethylsilylpropargyl alcohol(5272-36-6) |
| EPA Substance Registry System | 2-Propyn-1-ol, 3-(trimethylsilyl)- (5272-36-6) |
Safety information for 3-TRIMETHYLSILYL-2-PROPYN-1-OL
| Signal word | Warning |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H227:Flammable liquids H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P309:IF exposed or if you feel unwell: P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-TRIMETHYLSILYL-2-PROPYN-1-OL
| InChIKey | ZVGCJDPEKKEYES-UHFFFAOYSA-N |
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