3-Phenyl-1H-pyrazole

Synonym(s):3-Phenyl-1H-pyrazole

CAS NO.：2458-26-6
Empirical Formula: C9H8N2
Molecular Weight: 144.17
MDL number: MFCD00159654
EINECS: 627-985-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:25:58

What is 3-Phenyl-1H-pyrazole?

Description

3-phenyl-1H-pyrazole is an essential intermediate for the synthesis of many biologically active compounds. It was synthesized from acetophenone and hydrazine through two steps, including Knoevenagel condensation and cyclization reaction[1]. As the ligand, this compound could synthesize a novel luminescent cyclometalated iridium(III) complex-based chemosensor bearing a zinc-specific receptor. This Luminescent Iridium(III) Chemosensor could visualize Zn2+ Ions in Live Zebrafish[2].

Chemical properties

white to yellowish-orange powder

References

[1] X. Liu. et al. “Synthesis of 3-phenyl-1H-pyrazole Derivatives.”. DOI 10.2991/emcm-16.2017.117.
[2] Dik-Lung Ma*. “Visualization of Zn2+ Ions in Live Zebrafish Using a Luminescent Iridium(III) Chemosensor.” ACS Applied Materials & Interfaces 6 16 (2014): 14008–14015.

Properties of 3-Phenyl-1H-pyrazole

Melting point:	75-77 °C
Boiling point:	314°C(lit.)
Density	1.1357 (rough estimate)
refractive index	1.5960 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	13.52±0.10(Predicted)
form	Powder
color	White to yellow-orange
InChI	InChI=1S/C9H8N2/c1-2-4-8(5-3-1)9-6-7-10-11-9/h1-7H,(H,10,11)
CAS DataBase Reference	2458-26-6(CAS DataBase Reference)
NIST Chemistry Reference	3(5)-phenylpyrazole(2458-26-6)

Safety information for 3-Phenyl-1H-pyrazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.