3-Nitro-L-tyrosine

CAS NO.：621-44-3
Empirical Formula: C9H10N2O5
Molecular Weight: 226.19
MDL number: MFCD00007123
EINECS: 210-688-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:10:51

What is 3-Nitro-L-tyrosine?

Description

Nitrotyrosine is formed by peroxynitrite-mediated nitration of protein tyrosine residues. Its presence on proteins can be used as a marker for peroxynitrite formation in vivo. Both free and protein-bound nitrotyrosine are commonly found in mammalian tissues and are increased in pathological conditions. The basal levels of free nitrotyrosine in human plasma is approximately 3 nM as determined by gas chromatography/mass spectrometry.

Chemical properties

ochre-yellow to yellow-green powder

The Uses of 3-Nitro-L-tyrosine

3-Nitro-L-tyrosine is used as an indicator of the formation of peroxynitrite by NO-dependent oxidative damage.

The Uses of 3-Nitro-L-tyrosine

A marker for peroxynitrite. Oxidant and cytotoxic agent.

What are the applications of Application

3-Nitro-L-tyrosine is an indicator of the formation of peroxynitrite by NO-dependent oxidative damage

Definition

ChEBI: 3-nitro-L-tyrosine is a 3-nitrotyrosine comprising L-tyrosine having a nitro group at the 3-position on the phenyl ring. It is a L-tyrosine derivative, a non-proteinogenic L-alpha-amino acid and a 3-nitrotyrosine. It is an enantiomer of a 3-nitro-D-tyrosine.

Biochem/physiol Actions

Oxidant and cytotoxic agent.

Properties of 3-Nitro-L-tyrosine

Melting point:	233-235 °C (dec.) (lit.)
Boiling point:	367.79°C (rough estimate)
alpha	4 º (c=1, 1N HCl)
Density	1.4160 (rough estimate)
refractive index	1.5373 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Aqueous Acid (Slightly), Water
pka	2.17±0.20(Predicted)
form	crystalline
color	yellow to green
Water Solubility	insoluble
BRN	2813157
CAS DataBase Reference	621-44-3(CAS DataBase Reference)

Safety information for 3-Nitro-L-tyrosine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.