3-HYDROXY-3-PHENYL-PROPIONITRILE
Synonym(s):β-Hydroxy-benzenepropanenitrile
- CAS NO.：17190-29-3
- Empirical Formula: C9H9NO
- Molecular Weight: 147.17
- MDL number: MFCD00544189
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:22:37
What is 3-HYDROXY-3-PHENYL-PROPIONITRILE?
Chemical properties
Orange Oil
The Uses of 3-HYDROXY-3-PHENYL-PROPIONITRILE
3-Phenyl-3-hydroxypropanenitrile (cas# 17190-29-3) is a compound useful in organic synthesis.
Definition
ChEBI: 3-hydroxy-3-phenylpropionitrile is a nitrile that is 3-phenylpropionitrile in which one of the methylene hydrogens at position 3 is replaced by a hydroxy group. It is a nitrile, a member of benzyl alcohols and a secondary alcohol. It is functionally related to a 3-phenylpropionitrile.
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 366, 1983 DOI: 10.1021/jo00151a017
Synthetic Communications, 24, p. 1433, 1994 DOI: 10.1080/00397919408011747
Tetrahedron Letters, 26, p. 155, 1985 DOI: 10.1016/S0040-4039(00)61867-1
General Description
3-Hydroxy-3-phenylpropionitrile, a β-hydroxynitrile, is an aryl substituted α-aminophenylaceronitrile. It can be obtained by reacting lithioacetonitrile with benzaldehyde via asymmetric 1,2-addition reaction.
Properties of 3-HYDROXY-3-PHENYL-PROPIONITRILE
| Boiling point: | 306-307 °C (lit.) |
| Density | 1.112 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Sealed in dry,2-8°C |
| solubility | soluble in Chloroform, Dichloromethane, Ethyl Acetate |
| pka | 13.00±0.20(Predicted) |
| color | Colourless |
Safety information for 3-HYDROXY-3-PHENYL-PROPIONITRILE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 3-HYDROXY-3-PHENYL-PROPIONITRILE
New Products
Mirtazapine Impurity C/Mirtazapine Lactam Impurity Tetrabutylammonium perchlorate DL-beta-(3-Bromophenyl)alanine N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid (R)-1-Benzyl-3-pyrrolidinecarbonitrile N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy Benzylcyanide 3,4 Dimethoxy Benzylcyanide valeronitrile 4-Bromo BenzylcyanideRelated products of tetrahydrofuran
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