3-Hydroxy-3-methylglutaric acid
Synonym(s):3-Hydroxy-3-methylpentanedioic acid
- CAS NO.：503-49-1
- Empirical Formula: C6H10O5
- Molecular Weight: 162.14
- MDL number: MFCD00002712
- EINECS: 207-971-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:49:14
What is 3-Hydroxy-3-methylglutaric acid?
Description
Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.
Chemical properties
White Solid
Originator
Aligarh Muslim Univ. (India)
The Uses of 3-Hydroxy-3-methylglutaric acid
antihyperlipoproteinemia
The Uses of 3-Hydroxy-3-methylglutaric acid
3-Hydroxy-3-methylpentane-1,5-dioic Acid (cas# 503-49-1) is a compound useful in organic synthesis.
What are the applications of Application
3-Hydroxy-3-methylglutaric Acid is An antilipemic agent
Definition
ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
brand name
LIPOGLUTAREN
Synthesis Reference(s)
Synthesis, p. 791, 1981 DOI: 10.1055/s-1981-29596
Purification Methods
Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]
Properties of 3-Hydroxy-3-methylglutaric acid
| Melting point: | 105-108 °C (lit.) |
| Boiling point: | 120 °C / 13mmHg |
| Density | 1.2132 (rough estimate) |
| refractive index | 1.4230 (estimate) |
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml |
| pka | 3.95±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| Merck | 14,5808 |
| BRN | 1769194 |
| CAS DataBase Reference | 503-49-1(CAS DataBase Reference) |
Safety information for 3-Hydroxy-3-methylglutaric acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 3-Hydroxy-3-methylglutaric acid
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