3-HYDROXY-3-METHYLGLUTARIC ACID
Synonym(s):3-Hydroxy-3-methylpentanedioic acid
- CAS NO.：503-49-1
- Empirical Formula: C6H10O5
- Molecular Weight: 162.14
- MDL number: MFCD00002712
- EINECS: 207-971-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-15 14:49:44
What is 3-HYDROXY-3-METHYLGLUTARIC ACID?
Description
Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.
Chemical properties
White Solid
Originator
Aligarh Muslim Univ. (India)
The Uses of 3-HYDROXY-3-METHYLGLUTARIC ACID
antihyperlipoproteinemia
The Uses of 3-HYDROXY-3-METHYLGLUTARIC ACID
3-Hydroxy-3-methylpentane-1,5-dioic Acid (cas# 503-49-1) is a compound useful in organic synthesis.
What are the applications of Application
3-Hydroxy-3-methylglutaric Acid is An antilipemic agent
Definition
ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
brand name
LIPOGLUTAREN
Synthesis Reference(s)
Synthesis, p. 791, 1981 DOI: 10.1055/s-1981-29596
Purification Methods
Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]
Properties of 3-HYDROXY-3-METHYLGLUTARIC ACID
| Melting point: | 105-108 °C (lit.) |
| Boiling point: | 120 °C / 13mmHg |
| Density | 1.2132 (rough estimate) |
| refractive index | 1.4230 (estimate) |
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml |
| pka | 3.95±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| Merck | 14,5808 |
| BRN | 1769194 |
| CAS DataBase Reference | 503-49-1(CAS DataBase Reference) |
Safety information for 3-HYDROXY-3-METHYLGLUTARIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 3-HYDROXY-3-METHYLGLUTARIC ACID
New Products
DL-beta-(3-Bromophenyl)alanine Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) N,N CARBONYL DIIMIDAZOLE Levothyroxine Impurity-F Montelukast EP Impurity-D/Montelukast USP Related Compound C Atorvastatin FXA Impurity/Atorvastatin Cyclic 6-Hydroxy Impurity Sodium Salt Isosulfan blue Keto N-Oxide Impurity Ivermectin Impurity F N-Nitroso des Methyl Tramadol/N-Nitroso-N-Desmethyl-Tramadol (R)-BoroLeu-(+)-Pinanediol-CF3COOH 1,4-bis(methylsulfonyl)butane 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene CSA (DL-10-Camphorsulfonic Acid) 2-Hydroxy-4-methylnicotinic acid 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2S)-1-((2S,3S)-3-(2-methylbutyl)-4-oxooxetan-2-yl)pentadecan-2-yl formylleucinate 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethane-1-sulfonyl chloride S-(1-(3,5-dichlorophenyl)-2,2,2-trifluoroethyl) ethanethioateRelated products of tetrahydrofuran
You may like
-
3-Hydroxy-3-methylglutaric Acid CAS 503-49-1View Details
503-49-1 -
3-Hydroxy-3-methylglutaric acid CAS 503-49-1View Details
503-49-1 -
674783-97-2 98+View Details
674783-97-2 -
H-D-TRP(FOR)-OH HCL 98+View Details
367453-01-8 -
49830-37-7 98+View Details
49830-37-7 -
3-Amino-3-(4-fluorophenyl)propanoic acid 98+View Details
325-89-3 -
1428243-26-8 98+View Details
1428243-26-8 -
1-aminocyclopentane carbonitrile, HCl 98+View Details
16195-83-8