3-Fluoro-4-methoxyacetophenone
- CAS NO.：455-91-4
- Empirical Formula: C9H9FO2
- Molecular Weight: 168.16
- MDL number: MFCD00026219
- EINECS: 207-253-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:29:46
What is 3-Fluoro-4-methoxyacetophenone?
The Uses of 3-Fluoro-4-methoxyacetophenone
3’-Fluoro-4’methoxyacetophenone is used in the synthesis chalcones,
Preparation
Obtained by fluorination of 4-methoxyacetophenone with manganese (IV) tetrafluoride formed in situ using manganese (IV) dioxide and pyridinium polyhydrogenofluoride under very mild conditions.
General Description
3′-Fluoro-4′-methoxyacetophenone can be prepared by Friedel-Crafts reaction of o-fluoroanisole with acetic anhydride.
Properties of 3-Fluoro-4-methoxyacetophenone
| Melting point: | 92-94 °C(lit.) |
| Boiling point: | 147-148 °C20 mm Hg(lit.) |
| Density | 1.1410 (estimate) |
| Flash point: | 147-148°C/20mm |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 2084062 |
| CAS DataBase Reference | 455-91-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetophenone, 3'-fluoro-4'-methoxy-(455-91-4) |
Safety information for 3-Fluoro-4-methoxyacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Fluoro-4-methoxyacetophenone
3-Fluoro-4-methoxyacetophenone manufacturer
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: 3'-Fluoro-4'-methoxyacetophenone
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