3'-DEPHOSPHOCOENZYME A
Synonym(s):3′-Desphosphocoenzyme A;dpCoA
- CAS NO.：3633-59-8
- Empirical Formula: C21H35N7O13P2S
- Molecular Weight: 687.55
- MDL number: MFCD00057010
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-15 20:18:04
What is 3'-DEPHOSPHOCOENZYME A?
Description
3''-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A (CoA; Item Nos. 16147 | 21499 | 21722) from pantothenic acid (vitamin B5; ). It is phosphorylated by CoA synthase in humans to form CoA. 3''-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.
The Uses of 3'-DEPHOSPHOCOENZYME A
Dephosphocoenzyme A is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase (CoASy, 4′-phosphopantetheine adenylyltransferase/dephospho-CoA kinase) which performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A.
What are the applications of Application
3′-Dephosphocoenzyme A is A chemical reagent that is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase.
Definition
ChEBI: An adenosine 5'-phosphate that is coenzyme A in which the phosphate group at position 3' has been replaced by a hydrogen atom. It is an intermediate metabolite in pantothenate and CoA biosynthesis
Biochem/physiol Actions
3′-Dephosphocoenzyme A (DepCoA), also called desphosphoCoA (dpCoA), is synthesized from 4-phosphopantetheine by the enzyme phosphopanthetheine adenylyltransferase. It is an intermediate in coenzyme A biosynthetic pathway. In the presence of dephospho-CoA kinase (CoaE), dephosphocoenzyme A is converted to coenzyme A. 3′-Dephosphocoenzyme shares adenosine-diphosphate substructure as like the purines and is a non-canonical nucleotide and is an initiator of transcription initiation. It is routinely used in in vitro transcription studies to initiate RNA synthesis.
Properties of 3'-DEPHOSPHOCOENZYME A
| Density | 1.85±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Water: 50 mg/ml |
| form | A crystalline solid |
| pka | 1.16±0.50(Predicted) |
Safety information for 3'-DEPHOSPHOCOENZYME A
Computed Descriptors for 3'-DEPHOSPHOCOENZYME A
New Products
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