3-Cyanoindole
Synonym(s):3-Indolecarbonitrile;NSC 24935
- CAS NO.：5457-28-3
- Empirical Formula: C9H6N2
- Molecular Weight: 142.16
- MDL number: MFCD00022717
- EINECS: 212-232-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:24
What is 3-Cyanoindole?
Chemical properties
brown-grey to brown crystalline powder
The Uses of 3-Cyanoindole
3-Cyanoindole (cas# 5457-28-3) is a compound useful in organic synthesis.
The Uses of 3-Cyanoindole
Reactant for preparation of:
- Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
- Inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities
- 4-substituted β-lactams
- Biologically active Indoles
- Inhibitors of glycogen synthase kinase 3β (GSK-3)
- HIV-1 integrase inhibitors
- Indole fragments as inosine monophosphate dehydrogenase (IMPDH) inhibitors
- Aziridinomitosene skeleton
- Potential antiviral agents
Reactant for:
- Intramolecular oxidative C-H coupling reactions with applications in medium-ring synthesis techniques
What are the applications of Application
3-Cyanoindole is 3-Cyanoindole is a reactant for preparation of 4-substituted β-lactams, biologically active Indoles, inhibitors of glycogen synthase kinase 3β (GSK-3).
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 5, p. 656, 1973
Tetrahedron, 50, p. 6549, 1994 DOI: 10.1016/S0040-4020(01)89685-X
Tetrahedron Letters, 18, p. 4417, 1977 DOI: 10.1016/S0040-4039(01)83524-3
General Description
3-Cyanoindole undergoes regiospecific bromination to afford 6-bromo-3-cyanoindole. 3-Cyanoindole is formed during the flash vacuum thermolysis (FVT) of 3-azidoquinoline.
Properties of 3-Cyanoindole
| Melting point: | 179-182 °C (lit.) |
| Boiling point: | 249.72°C (rough estimate) |
| Density | 1.1777 (rough estimate) |
| refractive index | 1.6211 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.61±0.30(Predicted) |
| color | Orange to Brown |
| Water Solubility | Insoluble in water. |
| Sensitive | Air & Light Sensitive |
| BRN | 120888 |
| CAS DataBase Reference | 5457-28-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Indolecarbonitrile(5457-28-3) |
Safety information for 3-Cyanoindole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 3-Cyanoindole
3-Cyanoindole manufacturer
JSK Chemicals
3Y
Phone:+91-9879767984
Whatsapp: +91-9879767970
product: 3-Cyanoindole, 98% 5457-28-3 99%
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: 1H-Indole-3-carbonitrile
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