3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate

CAS NO.：641569-96-2
Empirical Formula: C11H16N4O5
Molecular Weight: 284.27
MDL number: MFCD11100711
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-14 15:27:00

What is 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate?

Chemical properties

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate Appearance white to almost white powder to crystals, melting point 199 °C, storage 2-8 °C.

The Uses of 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate is an organic synthetic material or pharmaceutical intermediate compound that can be used in the preparation of N-phenyl-2-pyrimidinamine derivatives and in the synthesis of nilotinib and its salts. Nilotinib is a tyrosine kinase inhibitor used for the treatment of drug-resistant chronic myelogenous leukemia (CML), and in particular, for the treatment of chronic phase and accelerated phase Philadelphia chromosome positive chronic myeloid leukemia (CML) in adult patients whose disease has progressed on or who cannot tolerate other therapies that included imatinib. Nilotinib is administrated as a hydrochloride salt in the form of capsules that are marketed in the USA and the EU under the name Tasigna?.

Properties of 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate

Melting point:	197.0 to 201.0 °C
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
color	White to Almost white

Safety information for 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate

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